Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2491109..2491632 Replicon chromosome
Accession NZ_CP125901
Organism Staphylococcus aureus strain CHAL2

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag QM338_RS12510 Protein ID WP_000074049.1
Coordinates 2491109..2491375 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag QM338_RS12515 Protein ID WP_000587616.1
Coordinates 2491375..2491632 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM338_RS12490 (2486416) 2486416..2487603 - 1188 WP_000026189.1 MFS transporter -
QM338_RS12495 (2487999) 2487999..2488775 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
QM338_RS12500 (2488768) 2488768..2489430 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
QM338_RS12505 (2489678) 2489678..2490754 - 1077 WP_001076673.1 M42 family metallopeptidase -
QM338_RS12510 (2491109) 2491109..2491375 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
QM338_RS12515 (2491375) 2491375..2491632 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QM338_RS12520 (2491991) 2491991..2492446 + 456 WP_000732076.1 DUF1307 domain-containing protein -
QM338_RS12525 (2492614) 2492614..2494191 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
QM338_RS12530 (2494386) 2494386..2495135 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T282466 WP_000074049.1 NZ_CP125901:c2491375-2491109 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT282466 WP_000587616.1 NZ_CP125901:c2491632-2491375 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References