Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2119536..2120050 Replicon chromosome
Accession NZ_CP125901
Organism Staphylococcus aureus strain CHAL2

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QM338_RS10565 Protein ID WP_000581792.1
Coordinates 2119536..2119745 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QM338_RS10570 Protein ID WP_000138932.1
Coordinates 2119757..2120050 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM338_RS10545 (2115044) 2115044..2116402 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QM338_RS10550 (2116417) 2116417..2117487 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
QM338_RS10555 (2117805) 2117805..2119007 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QM338_RS10560 (2119271) 2119271..2119408 - 138 WP_000828354.1 Lmo0850 family protein -
QM338_RS10565 (2119536) 2119536..2119745 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QM338_RS10570 (2119757) 2119757..2120050 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QM338_RS10575 (2120216) 2120216..2121700 + 1485 WP_000571549.1 cardiolipin synthase -
QM338_RS10580 (2121728) 2121728..2122375 + 648 WP_001187630.1 HD domain-containing protein -
QM338_RS10585 (2123088) 2123088..2123960 - 873 WP_000725802.1 membrane protein insertase YidC -
QM338_RS10590 (2124046) 2124046..2124687 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T282461 WP_000581792.1 NZ_CP125901:c2119745-2119536 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT282461 WP_000138932.1 NZ_CP125901:c2120050-2119757 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References