282460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2098277..2098806 Replicon chromosome
Accession NZ_CP125901
Organism Staphylococcus aureus strain CHAL2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QM338_RS10465 Protein ID WP_000621175.1
Coordinates 2098277..2098639 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QM338_RS10470 Protein ID WP_000948331.1
Coordinates 2098636..2098806 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM338_RS10445 (2095256) 2095256..2096026 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
QM338_RS10450 (2096001) 2096001..2096480 - 480 WP_001190829.1 anti-sigma B factor RsbW -
QM338_RS10455 (2096482) 2096482..2096808 - 327 WP_001052491.1 anti-sigma factor antagonist -
QM338_RS10460 (2096927) 2096927..2097928 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QM338_RS10465 (2098277) 2098277..2098639 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QM338_RS10470 (2098636) 2098636..2098806 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QM338_RS10475 (2098891) 2098891..2100039 - 1149 WP_001281154.1 alanine racemase -
QM338_RS10480 (2100105) 2100105..2100464 - 360 WP_000581197.1 holo-ACP synthase -
QM338_RS10485 (2100468) 2100468..2100959 - 492 WP_001205912.1 PH domain-containing protein -
QM338_RS10490 (2100946) 2100946..2102529 - 1584 WP_001294626.1 PH domain-containing protein -
QM338_RS10495 (2102522) 2102522..2103001 - 480 WP_001287087.1 hypothetical protein -
QM338_RS10500 (2103209) 2103209..2103769 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T282460 WP_000621175.1 NZ_CP125901:c2098639-2098277 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT282460 WP_000948331.1 NZ_CP125901:c2098806-2098636 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References