28246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 351013..351801 Replicon chromosome
Accession NC_018608
Organism Staphylococcus aureus 08BA02176

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag C248_RS01550 Protein ID WP_000525004.1
Coordinates 351013..351474 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag C248_RS01555 Protein ID WP_000333630.1
Coordinates 351487..351801 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C248_RS01525 346065..347999 + 1935 Protein_299 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
C248_RS01530 348093..349298 - 1206 WP_000264746.1 site-specific integrase -
C248_RS01535 349424..350038 + 615 WP_000191466.1 hypothetical protein -
C248_RS01540 350035..350181 - 147 WP_001013104.1 hypothetical protein -
C248_RS01545 350411..350995 - 585 WP_000825948.1 hypothetical protein -
C248_RS01550 351013..351474 - 462 WP_000525004.1 hypothetical protein Toxin
C248_RS01555 351487..351801 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
C248_RS01560 351953..352189 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
C248_RS01565 352203..352979 + 777 WP_001148544.1 Rha family transcriptional regulator -
C248_RS01570 353008..353151 + 144 WP_000939498.1 hypothetical protein -
C248_RS01575 353141..353350 - 210 WP_000642492.1 hypothetical protein -
C248_RS14845 353406..353555 + 150 WP_000771849.1 hypothetical protein -
C248_RS01580 353596..353808 - 213 WP_000362644.1 hypothetical protein -
C248_RS01585 353878..354075 + 198 WP_001148860.1 hypothetical protein -
C248_RS01590 354062..354442 - 381 WP_000773059.1 DUF2513 domain-containing protein -
C248_RS01595 354509..354754 + 246 WP_001025401.1 DUF2829 domain-containing protein -
C248_RS01600 354723..355088 - 366 WP_001128432.1 hypothetical protein -
C248_RS01605 355143..355358 + 216 WP_001097552.1 hypothetical protein -
C248_RS01610 355383..355646 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
C248_RS01615 355659..355820 + 162 WP_001285954.1 DUF1270 domain-containing protein -
C248_RS01620 355899..356222 + 324 WP_000175000.1 hypothetical protein -
C248_RS01625 356237..356599 + 363 WP_000985986.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 348093..392677 44584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T28246 WP_000525004.1 NC_018608:c351474-351013 [Staphylococcus aureus 08BA02176]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T28246 NC_018608:c351474-351013 [Staphylococcus aureus 08BA02176]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT28246 WP_000333630.1 NC_018608:c351801-351487 [Staphylococcus aureus 08BA02176]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT28246 NC_018608:c351801-351487 [Staphylococcus aureus 08BA02176]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References