Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1901534..1902310 Replicon chromosome
Accession NZ_CP125901
Organism Staphylococcus aureus strain CHAL2

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QM338_RS09255 Protein ID WP_000031108.1
Coordinates 1901534..1901686 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QM338_RS09260 Protein ID WP_001251224.1
Coordinates 1901711..1902310 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM338_RS09240 (1897736) 1897736..1898557 + 822 WP_000669376.1 RluA family pseudouridine synthase -
QM338_RS09245 (1899010) 1899010..1900395 - 1386 WP_000116228.1 class II fumarate hydratase -
QM338_RS09250 (1900591) 1900591..1900986 - 396 WP_000901023.1 hypothetical protein -
QM338_RS09255 (1901534) 1901534..1901686 - 153 WP_000031108.1 SAS053 family protein Toxin
QM338_RS09260 (1901711) 1901711..1902310 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QM338_RS09265 (1902469) 1902469..1902939 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QM338_RS09270 (1902944) 1902944..1904071 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
QM338_RS09275 (1904222) 1904222..1904944 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QM338_RS09280 (1904937) 1904937..1906394 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T282456 WP_000031108.1 NZ_CP125901:c1901686-1901534 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT282456 WP_001251224.1 NZ_CP125901:c1902310-1901711 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References