282453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 363650..364185 Replicon chromosome
Accession NZ_CP125901
Organism Staphylococcus aureus strain CHAL2

Toxin (Protein)


Gene name TscT Uniprot ID A0A4P7P340
Locus tag QM338_RS01650 Protein ID WP_001103945.1
Coordinates 363862..364185 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag QM338_RS01645 Protein ID WP_001058486.1
Coordinates 363650..363859 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM338_RS01605 (358701) 358701..359204 + 504 WP_000934799.1 single-stranded DNA-binding protein -
QM338_RS01610 (359256) 359256..359498 + 243 WP_000897044.1 30S ribosomal protein S18 -
QM338_RS01615 (359737) 359737..360637 - 901 Protein_320 Abi family protein -
QM338_RS01620 (360639) 360639..361853 - 1215 WP_031765313.1 site-specific integrase -
QM338_RS01625 (362117) 362117..362842 - 726 WP_000668215.1 helix-turn-helix transcriptional regulator -
QM338_RS01630 (363014) 363014..363226 + 213 WP_001245562.1 helix-turn-helix transcriptional regulator -
QM338_RS01635 (363227) 363227..363499 + 273 WP_001138300.1 helix-turn-helix domain-containing protein -
QM338_RS01640 (363511) 363511..363657 + 147 WP_000784875.1 hypothetical protein -
QM338_RS01645 (363650) 363650..363859 + 210 WP_001058486.1 hypothetical protein Antitoxin
QM338_RS01650 (363862) 363862..364185 + 324 WP_001103945.1 DUF1474 family protein Toxin
QM338_RS01655 (364250) 364250..365119 + 870 WP_031765319.1 primase alpha helix C-terminal domain-containing protein -
QM338_RS01660 (365136) 365136..366593 + 1458 WP_031765320.1 virulence-associated E family protein -
QM338_RS01665 (366894) 366894..367256 + 363 WP_031765322.1 hypothetical protein -
QM338_RS01670 (367258) 367258..367542 + 285 WP_000998179.1 hypothetical protein -
QM338_RS01675 (367539) 367539..368180 + 642 WP_031765326.1 pathogenicity island protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tsst-1 358701..377563 18862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12665.26 Da        Isoelectric Point: 4.7124

>T282453 WP_001103945.1 NZ_CP125901:363862-364185 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Download         Length: 324 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT282453 WP_001058486.1 NZ_CP125901:363650-363859 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7P340

Antitoxin

Source ID Structure

References