282451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2082259..2082773 Replicon chromosome
Accession NZ_CP125899
Organism Staphylococcus aureus strain CHAL3

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag QM339_RS10295 Protein ID WP_000581795.1
Coordinates 2082259..2082468 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag QM339_RS10300 Protein ID WP_000138930.1
Coordinates 2082480..2082773 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM339_RS10275 (2077767) 2077767..2079125 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QM339_RS10280 (2079140) 2079140..2080210 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
QM339_RS10285 (2080528) 2080528..2081730 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QM339_RS10290 (2081994) 2081994..2082131 - 138 WP_000828354.1 Lmo0850 family protein -
QM339_RS10295 (2082259) 2082259..2082468 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
QM339_RS10300 (2082480) 2082480..2082773 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
QM339_RS10305 (2082939) 2082939..2084423 + 1485 WP_000571562.1 cardiolipin synthase -
QM339_RS10310 (2084451) 2084451..2085098 + 648 WP_001187625.1 HD domain-containing protein -
QM339_RS10315 (2085648) 2085648..2086520 - 873 WP_000725802.1 membrane protein insertase YidC -
QM339_RS10320 (2086606) 2086606..2087247 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T282451 WP_000581795.1 NZ_CP125899:c2082468-2082259 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT282451 WP_000138930.1 NZ_CP125899:c2082773-2082480 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References