282450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2062516..2063045 Replicon chromosome
Accession NZ_CP125899
Organism Staphylococcus aureus strain CHAL3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QM339_RS10205 Protein ID WP_000621175.1
Coordinates 2062516..2062878 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QM339_RS10210 Protein ID WP_000948331.1
Coordinates 2062875..2063045 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM339_RS10185 (2059495) 2059495..2060265 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
QM339_RS10190 (2060240) 2060240..2060719 - 480 WP_001190825.1 anti-sigma B factor RsbW -
QM339_RS10195 (2060721) 2060721..2061047 - 327 WP_001052491.1 anti-sigma factor antagonist -
QM339_RS10200 (2061166) 2061166..2062167 - 1002 WP_283502257.1 PP2C family protein-serine/threonine phosphatase -
QM339_RS10205 (2062516) 2062516..2062878 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QM339_RS10210 (2062875) 2062875..2063045 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QM339_RS10215 (2063130) 2063130..2064278 - 1149 WP_001281140.1 alanine racemase -
QM339_RS10220 (2064344) 2064344..2064703 - 360 WP_000581199.1 holo-ACP synthase -
QM339_RS10225 (2064707) 2064707..2065198 - 492 WP_001205907.1 PH domain-containing protein -
QM339_RS10230 (2065185) 2065185..2066768 - 1584 WP_001294637.1 PH domain-containing protein -
QM339_RS10235 (2066761) 2066761..2067240 - 480 WP_001287077.1 hypothetical protein -
QM339_RS10240 (2067448) 2067448..2068008 - 561 WP_001092406.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T282450 WP_000621175.1 NZ_CP125899:c2062878-2062516 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT282450 WP_000948331.1 NZ_CP125899:c2063045-2062875 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References