Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1741530..1741981 Replicon chromosome
Accession NC_018607
Organism Brachyspira pilosicoli B2904

Toxin (Protein)


Gene name hicA Uniprot ID J9UUS4
Locus tag B2904_RS07925 Protein ID WP_014933300.1
Coordinates 1741530..1741763 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID J9UNY0
Locus tag B2904_RS07930 Protein ID WP_014933301.1
Coordinates 1741760..1741981 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2904_RS07915 1737169..1739586 + 2418 WP_014936229.1 PBP1A family penicillin-binding protein -
B2904_RS07920 1739593..1741446 + 1854 WP_014936230.1 conjugal transfer protein TraB -
B2904_RS07925 1741530..1741763 - 234 WP_014933300.1 type II toxin-antitoxin system HicA family toxin Toxin
B2904_RS07930 1741760..1741981 - 222 WP_014933301.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B2904_RS07935 1742254..1742646 - 393 WP_014936231.1 Hsp20/alpha crystallin family protein -
B2904_RS07940 1742668..1743069 - 402 WP_014933304.1 Hsp20/alpha crystallin family protein -
B2904_RS07945 1743380..1743838 + 459 WP_014936232.1 large conductance mechanosensitive channel protein MscL -
B2904_RS07950 1743973..1745118 + 1146 WP_014936233.1 alanine--glyoxylate aminotransferase family protein -
B2904_RS07955 1745249..1746853 + 1605 WP_014936234.1 phosphoglycerate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

Domain of unknown function DUF1902

(9-48)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9027.69 Da        Isoelectric Point: 10.1753

>T28245 WP_014933300.1 NC_018607:c1741763-1741530 [Brachyspira pilosicoli B2904]
MSKLILKDAKTIEKLLFLLGFVKQRQKGSHAFYKHEDGRCTVIPFHSSKVISRPLMRKILNEINLDVEEYNNLIEKI

Download         Length: 234 bp

>T28245 NC_018607:c1741763-1741530 [Brachyspira pilosicoli B2904]
ATGAGTAAGCTAATTTTGAAGGACGCAAAAACTATAGAAAAATTGTTGTTTTTATTAGGGTTTGTTAAACAGAGGCAGAA
AGGAAGTCATGCCTTTTATAAACATGAGGACGGACGATGCACTGTTATACCTTTTCACTCAAGCAAGGTAATATCAAGAC
CGCTTATGAGAAAAATATTAAATGAAATAAATCTTGATGTAGAAGAATATAATAATCTTATAGAAAAAATTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8479.80 Da        Isoelectric Point: 4.4108

>AT28245 WP_014933301.1 NC_018607:c1741981-1741760 [Brachyspira pilosicoli B2904]
MKKKFFAYIEYDKETNVYVGYIPSIVGAHTQADTLEELHIKLKEVLDLCLGEMDSEEKKTIPEFVKVEEIELV

Download         Length: 222 bp

>AT28245 NC_018607:c1741981-1741760 [Brachyspira pilosicoli B2904]
ATGAAGAAAAAGTTTTTTGCATATATAGAATATGATAAAGAAACCAATGTTTATGTGGGATATATTCCTTCAATAGTTGG
GGCACATACACAGGCTGACACTTTGGAAGAGTTGCATATAAAATTAAAAGAGGTTTTGGATTTATGTCTTGGAGAGATGG
ATAGCGAAGAAAAGAAGACTATTCCAGAGTTTGTAAAAGTAGAAGAGATAGAGCTTGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J9UUS4

Antitoxin

Source ID Structure
AlphaFold DB J9UNY0

References