Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1741530..1741981 Replicon chromosome
Accession NC_018607
Organism Brachyspira pilosicoli B2904

Toxin (Protein)


Gene name hicA Uniprot ID J9UUS4
Locus tag B2904_RS07925 Protein ID WP_014933300.1
Coordinates 1741530..1741763 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID J9UNY0
Locus tag B2904_RS07930 Protein ID WP_014933301.1
Coordinates 1741760..1741981 (-) Length 74 a.a.

Genomic Context

B2904_RS07915B2904_RS07920B2904_RS07945B2904_RS07950B2904_RS07955B2904_RS07925B2904_RS07930B2904_RS07935B2904_RS07940
Location: 1737169..1739586 (2418 bp)
Type: Others
Protein ID: WP_014936229.1
Location: 1739593..1741446 (1854 bp)
Type: Others
Protein ID: WP_014936230.1
Location: 1743380..1743838 (459 bp)
Type: Others
Protein ID: WP_014936232.1
Location: 1743973..1745118 (1146 bp)
Type: Others
Protein ID: WP_014936233.1
Location: 1745249..1746853 (1605 bp)
Type: Others
Protein ID: WP_014936234.1
Location: 1741530..1741763 (234 bp)
Type: Toxin
Protein ID: WP_014933300.1
Location: 1741760..1741981 (222 bp)
Type: Antitoxin
Protein ID: WP_014933301.1
Location: 1742254..1742646 (393 bp)
Type: Others
Protein ID: WP_014936231.1
Location: 1742668..1743069 (402 bp)
Type: Others
Protein ID: WP_014933304.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B2904_RS079151737169..1739586+2418WP_014936229.1PBP1A family penicillin-binding protein-
B2904_RS079201739593..1741446+1854WP_014936230.1conjugal transfer protein TraB-
B2904_RS079251741530..1741763-234WP_014933300.1type II toxin-antitoxin system HicA family toxinToxin
B2904_RS079301741760..1741981-222WP_014933301.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
B2904_RS079351742254..1742646-393WP_014936231.1Hsp20/alpha crystallin family protein-
B2904_RS079401742668..1743069-402WP_014933304.1Hsp20/alpha crystallin family protein-
B2904_RS079451743380..1743838+459WP_014936232.1large conductance mechanosensitive channel protein MscL-
B2904_RS079501743973..1745118+1146WP_014936233.1alanine--glyoxylate aminotransferase family protein-
B2904_RS079551745249..1746853+1605WP_014936234.1phosphoglycerate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

Domain of unknown function DUF1902

(9-48)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9027.69 Da        Isoelectric Point: 10.1753

>T28245 WP_014933300.1 NC_018607:c1741763-1741530 [Brachyspira pilosicoli B2904]
MSKLILKDAKTIEKLLFLLGFVKQRQKGSHAFYKHEDGRCTVIPFHSSKVISRPLMRKILNEINLDVEEYNNLIEKI

Download         Length: 234 bp

>T28245 NC_018607:c1741763-1741530 [Brachyspira pilosicoli B2904]
ATGAGTAAGCTAATTTTGAAGGACGCAAAAACTATAGAAAAATTGTTGTTTTTATTAGGGTTTGTTAAACAGAGGCAGAA
AGGAAGTCATGCCTTTTATAAACATGAGGACGGACGATGCACTGTTATACCTTTTCACTCAAGCAAGGTAATATCAAGAC
CGCTTATGAGAAAAATATTAAATGAAATAAATCTTGATGTAGAAGAATATAATAATCTTATAGAAAAAATTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8479.80 Da        Isoelectric Point: 4.4108

>AT28245 WP_014933301.1 NC_018607:c1741981-1741760 [Brachyspira pilosicoli B2904]
MKKKFFAYIEYDKETNVYVGYIPSIVGAHTQADTLEELHIKLKEVLDLCLGEMDSEEKKTIPEFVKVEEIELV

Download         Length: 222 bp

>AT28245 NC_018607:c1741981-1741760 [Brachyspira pilosicoli B2904]
ATGAAGAAAAAGTTTTTTGCATATATAGAATATGATAAAGAAACCAATGTTTATGTGGGATATATTCCTTCAATAGTTGG
GGCACATACACAGGCTGACACTTTGGAAGAGTTGCATATAAAATTAAAAGAGGTTTTGGATTTATGTCTTGGAGAGATGG
ATAGCGAAGAAAAGAAGACTATTCCAGAGTTTGTAAAAGTAGAAGAGATAGAGCTTGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBJ9UUS4

Antitoxin

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Source
ID
Structure
AlphaFold DBJ9UNY0

References