282448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 938562..939338 Replicon chromosome
Accession NZ_CP125899
Organism Staphylococcus aureus strain CHAL3

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag QM339_RS04720 Protein ID WP_000031109.1
Coordinates 939186..939338 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QM339_RS04715 Protein ID WP_001251224.1
Coordinates 938562..939161 (+) Length 200 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM339_RS04695 (934478) 934478..935935 + 1458 WP_000649916.1 ABC transporter permease subunit -
QM339_RS04700 (935928) 935928..936650 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QM339_RS04705 (936801) 936801..937928 + 1128 Protein_885 tRNA epoxyqueuosine(34) reductase QueG -
QM339_RS04710 (937933) 937933..938403 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QM339_RS04715 (938562) 938562..939161 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QM339_RS04720 (939186) 939186..939338 + 153 WP_000031109.1 SAS053 family protein Toxin
QM339_RS04725 (940337) 940337..940732 + 396 WP_000901019.1 hypothetical protein -
QM339_RS04730 (940928) 940928..942313 + 1386 WP_000116239.1 class II fumarate hydratase -
QM339_RS04735 (942770) 942770..943591 - 822 WP_000669377.1 RluA family pseudouridine synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5950.31 Da        Isoelectric Point: 3.9075

>T282448 WP_000031109.1 NZ_CP125899:939186-939338 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Download         Length: 153 bp


Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT282448 WP_001251224.1 NZ_CP125899:938562-939161 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References