282443

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 806004..806533 Replicon chromosome
Accession NZ_CP125899
Organism Staphylococcus aureus strain CHAL3

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX6
Locus tag QM339_RS03845 Protein ID WP_001103939.1
Coordinates 806216..806533 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IY59
Locus tag QM339_RS03840 Protein ID WP_001058494.1
Coordinates 806004..806213 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM339_RS03805 (802334) 802334..802798 + 465 WP_001085185.1 SsrA-binding protein SmpB -
QM339_RS03815 (803361) 803361..804467 - 1107 WP_000149511.1 tyrosine-type recombinase/integrase -
QM339_RS03820 (804457) 804457..805260 - 804 WP_000358990.1 helix-turn-helix transcriptional regulator -
QM339_RS03825 (805397) 805397..805621 + 225 WP_049304875.1 transcriptional regulator -
QM339_RS03830 (805635) 805635..805853 + 219 WP_000163544.1 helix-turn-helix transcriptional regulator -
QM339_RS03835 (805865) 805865..806011 + 147 WP_000784885.1 hypothetical protein -
QM339_RS03840 (806004) 806004..806213 + 210 WP_001058494.1 hypothetical protein Antitoxin
QM339_RS03845 (806216) 806216..806533 + 318 WP_001103939.1 DUF1474 family protein Toxin
QM339_RS03850 (806597) 806597..807466 + 870 WP_001002717.1 primase alpha helix C-terminal domain-containing protein -
QM339_RS03855 (807483) 807483..808940 + 1458 WP_000390453.1 virulence-associated E family protein -
QM339_RS03865 (810467) 810467..810829 + 363 WP_001039170.1 hypothetical protein -
QM339_RS03870 (810831) 810831..811115 + 285 WP_000998185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / chp / scn 803361..842992 39631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12547.17 Da        Isoelectric Point: 5.0161

>T282443 WP_001103939.1 NZ_CP125899:806216-806533 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Download         Length: 318 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8268.31 Da        Isoelectric Point: 4.3718

>AT282443 WP_001058494.1 NZ_CP125899:806004-806213 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX6

Antitoxin

Source ID Structure
AlphaFold DB X5IY59

References