Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1351093..1352330 Replicon chromosome
Accession NC_018594
Organism Streptococcus pneumoniae SPNA45

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag SPNA45_RS07580 Protein ID WP_000405627.1
Coordinates 1351569..1352330 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag SPNA45_RS07575 Protein ID WP_000579614.1
Coordinates 1351093..1351569 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPNA45_RS07550 1346166..1347020 + 855 WP_000900015.1 ADP-ribosylglycohydrolase family protein -
SPNA45_RS07555 1347132..1348016 + 885 WP_000710113.1 diacylglycerol kinase family lipid kinase -
SPNA45_RS07560 1348179..1349918 + 1740 WP_000423469.1 glycoside hydrolase family 13 protein -
SPNA45_RS07570 1350193..1350648 + 456 WP_000500473.1 hypothetical protein -
SPNA45_RS07575 1351093..1351569 + 477 WP_000579614.1 helix-turn-helix domain-containing protein Antitoxin
SPNA45_RS07580 1351569..1352330 + 762 WP_000405627.1 zeta toxin family protein Toxin
SPNA45_RS12480 1352358..1353134 + 777 Protein_1397 hypothetical protein -
SPNA45_RS07595 1353062..1353514 + 453 WP_078169748.1 hypothetical protein -
SPNA45_RS07600 1354333..1354692 + 360 WP_000003750.1 hypothetical protein -
SPNA45_RS07605 1354702..1355055 + 354 WP_000263056.1 MobC family plasmid mobilization relaxosome protein -
SPNA45_RS13845 1355042..1356908 + 1867 Protein_1401 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1328588..1449153 120565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29078.03 Da        Isoelectric Point: 6.7759

>T28244 WP_000405627.1 NC_018594:1351569-1352330 [Streptococcus pneumoniae SPNA45]
MEIQYYTDSEFKHALTRNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHHLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKETAQLLKSKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T28244 NC_018594:1351569-1352330 [Streptococcus pneumoniae SPNA45]
ATGGAAATCCAATATTATACTGATAGTGAATTCAAACATGCTCTAACACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACCATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGACGTTCCAAAGGAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAACTGGAAGAACTGGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18236.67 Da        Isoelectric Point: 4.3462

>AT28244 WP_000579614.1 NC_018594:1351093-1351569 [Streptococcus pneumoniae SPNA45]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT28244 NC_018594:1351093-1351569 [Streptococcus pneumoniae SPNA45]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACCGAATTAATAGATATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGCATGTTAGAGATATCTGAAAAACGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References