282438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2141685..2142199 Replicon chromosome
Accession NZ_CP125897
Organism Staphylococcus aureus strain CHAL4

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QM341_RS10790 Protein ID WP_000581792.1
Coordinates 2141685..2141894 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QM341_RS10795 Protein ID WP_000138932.1
Coordinates 2141906..2142199 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM341_RS10770 (2137193) 2137193..2138551 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QM341_RS10775 (2138566) 2138566..2139636 - 1071 WP_000159633.1 D-alanine--D-alanine ligase -
QM341_RS10780 (2139954) 2139954..2141156 + 1203 WP_001109935.1 FtsW/RodA/SpoVE family cell cycle protein -
QM341_RS10785 (2141420) 2141420..2141557 - 138 WP_000828354.1 Lmo0850 family protein -
QM341_RS10790 (2141685) 2141685..2141894 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QM341_RS10795 (2141906) 2141906..2142199 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QM341_RS10800 (2142365) 2142365..2143849 + 1485 WP_283487074.1 cardiolipin synthase -
QM341_RS10805 (2143877) 2143877..2144524 + 648 WP_001187629.1 HD domain-containing protein -
QM341_RS10810 (2145337) 2145337..2146209 - 873 WP_000725802.1 membrane protein insertase YidC -
QM341_RS10815 (2146295) 2146295..2146936 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T282438 WP_000581792.1 NZ_CP125897:c2141894-2141685 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT282438 WP_000138932.1 NZ_CP125897:c2142199-2141906 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References