Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2121929..2122458 Replicon chromosome
Accession NZ_CP125897
Organism Staphylococcus aureus strain CHAL4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QM341_RS10700 Protein ID WP_000621175.1
Coordinates 2121929..2122291 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QM341_RS10705 Protein ID WP_000948331.1
Coordinates 2122288..2122458 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM341_RS10680 (2118907) 2118907..2119677 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
QM341_RS10685 (2119652) 2119652..2120131 - 480 WP_001190829.1 anti-sigma B factor RsbW -
QM341_RS10690 (2120133) 2120133..2120459 - 327 WP_001052491.1 anti-sigma factor antagonist -
QM341_RS10695 (2120578) 2120578..2121579 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QM341_RS10700 (2121929) 2121929..2122291 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QM341_RS10705 (2122288) 2122288..2122458 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QM341_RS10710 (2122543) 2122543..2123691 - 1149 WP_001281145.1 alanine racemase -
QM341_RS10715 (2123757) 2123757..2124116 - 360 WP_000581200.1 holo-ACP synthase -
QM341_RS10720 (2124120) 2124120..2124611 - 492 WP_001205910.1 PH domain-containing protein -
QM341_RS10725 (2124598) 2124598..2126181 - 1584 WP_001294626.1 PH domain-containing protein -
QM341_RS10730 (2126174) 2126174..2126653 - 480 WP_001287088.1 hypothetical protein -
QM341_RS10735 (2126861) 2126861..2127421 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T282437 WP_000621175.1 NZ_CP125897:c2122291-2121929 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT282437 WP_000948331.1 NZ_CP125897:c2122458-2122288 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References