Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1920272..1921048 Replicon chromosome
Accession NZ_CP125897
Organism Staphylococcus aureus strain CHAL4

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QM341_RS09425 Protein ID WP_000031108.1
Coordinates 1920272..1920424 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QM341_RS09430 Protein ID WP_001251224.1
Coordinates 1920449..1921048 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM341_RS09410 (1916235) 1916235..1917056 + 822 WP_000669376.1 RluA family pseudouridine synthase -
QM341_RS09415 (1917519) 1917519..1918904 - 1386 WP_000116224.1 class II fumarate hydratase -
QM341_RS09420 (1919100) 1919100..1919495 - 396 WP_000901021.1 hypothetical protein -
QM341_RS09425 (1920272) 1920272..1920424 - 153 WP_000031108.1 SAS053 family protein Toxin
QM341_RS09430 (1920449) 1920449..1921048 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QM341_RS09435 (1921207) 1921207..1921677 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QM341_RS09440 (1921682) 1921682..1922809 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
QM341_RS09445 (1922960) 1922960..1923682 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QM341_RS09450 (1923675) 1923675..1925132 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T282433 WP_000031108.1 NZ_CP125897:c1920424-1920272 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT282433 WP_001251224.1 NZ_CP125897:c1921048-1920449 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References