Detailed information of TA system TA028243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 951624..952122
• Replicon: chromosome
• Accession: NC_018594
• Organism: Streptococcus pneumoniae SPNA45

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPNA45_RS05430
• Protein ID: WP_041852840.1
• Coordinates: 951868..952122 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: SPNA45_RS05425
• Protein ID: WP_000208080.1
• Coordinates: 951624..951866 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPNA45_RS05405	947445..948620	+	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
SPNA45_RS05410	948676..949380	+	705	WP_000722076.1	response regulator transcription factor	-
SPNA45_RS05415	949373..950722	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
SPNA45_RS05420	950724..951533	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
SPNA45_RS05425	951624..951866	+	243	WP_000208080.1	hypothetical protein	Antitoxin
SPNA45_RS05430	951868..952122	+	255	WP_041852840.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPNA45_RS05435	952197..954068	+	1872	WP_000150981.1	Eco57I restriction-modification methylase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10089.78 Da
• Isoelectric Point: 10.7632

>T28243 WP_041852840.1 NC_018594:951868-952122 [Streptococcus pneumoniae SPNA45]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRQGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T28243 NC_018594:951868-952122 [Streptococcus pneumoniae SPNA45]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACAAGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT28243 WP_000208080.1 NC_018594:951624-951866 [Streptococcus pneumoniae SPNA45]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT28243 NC_018594:951624-951866 [Streptococcus pneumoniae SPNA45]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7