Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2087827..2088341 Replicon chromosome
Accession NZ_CP125895
Organism Staphylococcus aureus strain CHAL5

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag QM342_RS10260 Protein ID WP_000581793.1
Coordinates 2087827..2088036 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag QM342_RS10265 Protein ID WP_234728055.1
Coordinates 2088048..2088341 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM342_RS10240 (2083336) 2083336..2084694 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QM342_RS10245 (2084709) 2084709..2085779 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
QM342_RS10250 (2086097) 2086097..2087299 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QM342_RS10255 (2087562) 2087562..2087699 - 138 WP_000828354.1 Lmo0850 family protein -
QM342_RS10260 (2087827) 2087827..2088036 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
QM342_RS10265 (2088048) 2088048..2088341 - 294 WP_234728055.1 copper-sensing transcriptional repressor CsoR Antitoxin
QM342_RS10270 (2088507) 2088507..2089991 + 1485 WP_000571552.1 cardiolipin synthase -
QM342_RS10275 (2090019) 2090019..2090666 + 648 WP_001187627.1 HD domain-containing protein -
QM342_RS10280 (2091378) 2091378..2092250 - 873 WP_000725802.1 membrane protein insertase YidC -
QM342_RS10285 (2092336) 2092336..2092977 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T282423 WP_000581793.1 NZ_CP125895:c2088036-2087827 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11243.91 Da        Isoelectric Point: 6.2215

>AT282423 WP_234728055.1 NZ_CP125895:c2088341-2088048 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQCAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure

References