Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2068087..2068616 Replicon chromosome
Accession NZ_CP125895
Organism Staphylococcus aureus strain CHAL5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QM342_RS10170 Protein ID WP_000621175.1
Coordinates 2068087..2068449 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QM342_RS10175 Protein ID WP_000948331.1
Coordinates 2068446..2068616 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM342_RS10150 (2065066) 2065066..2065836 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
QM342_RS10155 (2065811) 2065811..2066290 - 480 WP_001190829.1 anti-sigma B factor RsbW -
QM342_RS10160 (2066292) 2066292..2066618 - 327 WP_001052491.1 anti-sigma factor antagonist -
QM342_RS10165 (2066737) 2066737..2067738 - 1002 WP_061839378.1 PP2C family protein-serine/threonine phosphatase -
QM342_RS10170 (2068087) 2068087..2068449 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QM342_RS10175 (2068446) 2068446..2068616 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QM342_RS10180 (2068701) 2068701..2069849 - 1149 WP_001281151.1 alanine racemase -
QM342_RS10185 (2069915) 2069915..2070274 - 360 WP_000581200.1 holo-ACP synthase -
QM342_RS10190 (2070278) 2070278..2070769 - 492 WP_001205910.1 PH domain-containing protein -
QM342_RS10195 (2070756) 2070756..2072339 - 1584 WP_001294626.1 PH domain-containing protein -
QM342_RS10200 (2072332) 2072332..2072811 - 480 WP_001287090.1 hypothetical protein -
QM342_RS10205 (2073020) 2073020..2073580 - 561 WP_001092416.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T282422 WP_000621175.1 NZ_CP125895:c2068449-2068087 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT282422 WP_000948331.1 NZ_CP125895:c2068616-2068446 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References