Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1871126..1871902 Replicon chromosome
Accession NZ_CP125895
Organism Staphylococcus aureus strain CHAL5

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QM342_RS08950 Protein ID WP_000031108.1
Coordinates 1871126..1871278 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QM342_RS08955 Protein ID WP_001251224.1
Coordinates 1871303..1871902 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM342_RS08935 (1867330) 1867330..1868151 + 822 WP_000669373.1 RluA family pseudouridine synthase -
QM342_RS08940 (1868604) 1868604..1869989 - 1386 WP_000116230.1 class II fumarate hydratase -
QM342_RS08945 (1870185) 1870185..1870580 - 396 WP_000901023.1 hypothetical protein -
QM342_RS08950 (1871126) 1871126..1871278 - 153 WP_000031108.1 SAS053 family protein Toxin
QM342_RS08955 (1871303) 1871303..1871902 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QM342_RS08960 (1872061) 1872061..1872531 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QM342_RS08965 (1872536) 1872536..1873663 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
QM342_RS08970 (1873814) 1873814..1874536 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QM342_RS08975 (1874529) 1874529..1875986 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T282418 WP_000031108.1 NZ_CP125895:c1871278-1871126 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT282418 WP_001251224.1 NZ_CP125895:c1871902-1871303 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References