Detailed information of TA system TA028241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 24205..24767
• Replicon: plasmid pGKT1
• Accession: NC_018582
• Organism: Gordonia sp. KTR9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KTR9_RS25205
• Protein ID: WP_044508599.1
• Coordinates: 24477..24767 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KTR9_RS25200
• Protein ID: WP_044508597.1
• Coordinates: 24205..24480 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR9_RS25175	19305..20117	+	813	WP_158409765.1	PASTA domain-containing protein	-
KTR9_RS25180	20207..20878	+	672	WP_014928789.1	hypothetical protein	-
KTR9_RS25185	20920..21315	-	396	WP_049942634.1	hypothetical protein	-
KTR9_RS27140	21312..21554	-	243	WP_014928791.1	hypothetical protein	-
KTR9_RS25190	21697..22845	-	1149	WP_014928792.1	DUF262 domain-containing protein	-
KTR9_RS25195	22842..23927	-	1086	WP_014928793.1	adenine-specific methyltransferase EcoRI family protein	-
KTR9_RS25200	24205..24480	+	276	WP_044508597.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KTR9_RS25205	24477..24767	+	291	WP_044508599.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KTR9_RS27785	24854..25051	-	198	WP_044508602.1	hypothetical protein	-
KTR9_RS25215	25151..25354	+	204	WP_044508604.1	hypothetical protein	-
KTR9_RS25220	25517..25855	+	339	WP_044508606.1	hypothetical protein	-
KTR9_RS25225	26289..26900	+	612	WP_014928796.1	hypothetical protein	-
KTR9_RS25230	26919..27587	-	669	WP_148281330.1	hypothetical protein	-
KTR9_RS27650	27604..28599	-	996	WP_158409766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..89480	89480

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-94)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10850.27 Da
• Isoelectric Point: 9.6933

>T28241 WP_044508599.1 NC_018582:24477-24767 [Gordonia sp. KTR9]
VSDTPTDSADPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRDDLDGLHSARRGDYRILLRIDDPNH
TIVIVKIDHRAHAYRT

Nucleotide

• Length: 291 bp

>T28241 NC_018582:24477-24767 [Gordonia sp. KTR9]
GTGAGCGACACGCCCACGGACTCGGCCGACCCGTACCGAGTCGAGGTCGCATCCCCCGCACGCCGCGACCTGCAACGACT
TCCGTCTCGGATCGTGCACGCCGTCATCGAGTTCATCTCCGGACCACTCGCCGGCAACCCTCACCGACTCAGCAAACCGC
TGCGCGACGACCTCGACGGCCTCCACAGCGCACGCCGCGGCGACTACCGCATCCTGCTGCGCATCGACGACCCCAACCAC
ACCATCGTCATCGTCAAGATCGACCACCGCGCCCACGCCTACCGCACCTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9788.01 Da
• Isoelectric Point: 4.4936

>AT28241 WP_044508597.1 NC_018582:24205-24480 [Gordonia sp. KTR9]
MTTVPLGEAKDKLSALIDSAESTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGTRDAVAAADAEYADVQTISLE
ELRAEHGMPPK

Nucleotide

• Length: 276 bp

>AT28241 NC_018582:24205-24480 [Gordonia sp. KTR9]
ATGACGACAGTGCCGCTGGGTGAAGCCAAGGACAAGCTCTCCGCGCTCATCGACAGCGCCGAGAGCACGCACGACATCAT
CACGATCACCAAGCACGGCAAACCTGCCGCGGTGCTCATGTCGGCTGACGATCTCGAATCGCTGCACGAAACGATCTACT
GGCTCTCACGTGCCGGCACCCGCGACGCCGTTGCGGCCGCCGACGCCGAGTACGCCGACGTCCAGACCATTTCGCTCGAG
GAGCTGCGCGCCGAACACGGTATGCCGCCCAAGTGA