Detailed information of TA system TA282409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 3207377..3209052
• Replicon: chromosome
• Accession: NZ_CP125856
• Organism: Vibrio parahaemolyticus strain G855

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: QMY43_RS15140
• Protein ID: WP_175245863.1
• Coordinates: 3207841..3209052 (+)
• Length: 404 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0X8LPP8
• Locus tag: QMY43_RS15135
• Protein ID: WP_000649312.1
• Coordinates: 3207377..3207844 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMY43_RS15120 (QMY43_15120)	3204574..3205059	+	486	WP_233357514.1	hypothetical protein	-
QMY43_RS15125 (QMY43_15125)	3205056..3206420	+	1365	WP_193242283.1	hypothetical protein	-
QMY43_RS15130 (QMY43_15130)	3206420..3207187	+	768	WP_193242284.1	TatD family hydrolase	-
QMY43_RS15135 (QMY43_15135)	3207377..3207844	+	468	WP_000649312.1	DUF4065 domain-containing protein	Antitoxin
QMY43_RS15140 (QMY43_15140)	3207841..3209052	+	1212	WP_175245863.1	RelA/SpoT domain-containing protein	Toxin
QMY43_RS15145 (QMY43_15145)	3209297..3210406	-	1110	WP_025610459.1	tRNA (uridine(54)-C5)-methyltransferase TrmA	-
QMY43_RS15150 (QMY43_15150)	3210850..3212724	+	1875	WP_140104106.1	TonB-dependent receptor	-
QMY43_RS15155 (QMY43_15155)	3212803..3213486	+	684	WP_140104107.1	adenine nucleotide alpha hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3191040..3209052	18012

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (86-226)

Antitoxin

• Antitoxin SocA-like, Panacea domain (32-123)

Sequences

Toxin

Protein

• Length: 404 a.a.
• Molecular weight: 45823.63 Da
• Isoelectric Point: 5.2737

>T282409 WP_175245863.1 NZ_CP125856:3207841-3209052 [Vibrio parahaemolyticus]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYSNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDDDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN

Nucleotide

• Length: 1212 bp

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17581.02 Da
• Isoelectric Point: 7.5659

>AT282409 WP_000649312.1 NZ_CP125856:3207377-3207844 [Vibrio parahaemolyticus]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Nucleotide

• Length: 468 bp

Structures

Antitoxin

• AlphaFold DB: A0A0X8LPP8