Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1570096..1570697 Replicon chromosome
Accession NZ_CP125806
Organism Pasteurella multocida strain P030653/2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QM029_RS07560 Protein ID WP_078819687.1
Coordinates 1570096..1570410 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QM029_RS07565 Protein ID WP_078819686.1
Coordinates 1570407..1570697 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM029_RS07520 (QM029_07520) 1565321..1565689 - 369 Protein_1444 Bro-N domain-containing protein -
QM029_RS07525 (QM029_07525) 1566093..1566749 - 657 WP_014390711.1 Bro-N domain-containing protein -
QM029_RS07530 (QM029_07530) 1567034..1567870 - 837 WP_014390712.1 KilA-N domain-containing protein -
QM029_RS07535 (QM029_07535) 1567981..1568358 - 378 WP_014390713.1 hypothetical protein -
QM029_RS07540 (QM029_07540) 1568333..1568524 - 192 WP_014390714.1 hypothetical protein -
QM029_RS07555 (QM029_07555) 1569411..1569638 - 228 WP_099821843.1 hypothetical protein -
QM029_RS07560 (QM029_07560) 1570096..1570410 + 315 WP_078819687.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QM029_RS07565 (QM029_07565) 1570407..1570697 + 291 WP_078819686.1 putative addiction module antidote protein Antitoxin
QM029_RS07570 (QM029_07570) 1570723..1571160 - 438 WP_078819883.1 hypothetical protein -
QM029_RS07575 (QM029_07575) 1571157..1573001 - 1845 WP_265362803.1 DEAD/DEAH box helicase family protein -
QM029_RS07580 (QM029_07580) 1573212..1573889 - 678 WP_014390718.1 XRE family transcriptional regulator -
QM029_RS07585 (QM029_07585) 1574013..1574210 + 198 WP_014390719.1 helix-turn-helix domain-containing protein -
QM029_RS07590 (QM029_07590) 1574260..1574712 + 453 WP_014390720.1 hypothetical protein -
QM029_RS07595 (QM029_07595) 1574771..1575472 + 702 WP_014667788.1 phage antirepressor KilAC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1546021..1599815 53794


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11763.65 Da        Isoelectric Point: 9.5553

>T282405 WP_078819687.1 NZ_CP125806:1570096-1570410 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEEINV

Download         Length: 315 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10574.22 Da        Isoelectric Point: 5.7134

>AT282405 WP_078819686.1 NZ_CP125806:1570407-1570697 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEILETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References