Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 968000..968574 Replicon chromosome
Accession NZ_CP125806
Organism Pasteurella multocida strain P030653/2

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag QM029_RS04745 Protein ID WP_014667974.1
Coordinates 968290..968574 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag QM029_RS04740 Protein ID WP_014391174.1
Coordinates 968000..968293 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM029_RS04720 (QM029_04720) 963166..964257 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
QM029_RS04725 (QM029_04725) 964606..966396 + 1791 WP_014391171.1 PTS ascorbate-specific subunit IIBC -
QM029_RS04730 (QM029_04730) 966441..966908 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
QM029_RS04735 (QM029_04735) 966926..967603 + 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
QM029_RS04740 (QM029_04740) 968000..968293 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
QM029_RS04745 (QM029_04745) 968290..968574 - 285 WP_014667974.1 addiction module protein Toxin
QM029_RS04755 (QM029_04755) 969868..970129 - 262 Protein_904 hypothetical protein -
QM029_RS04760 (QM029_04760) 970473..970625 - 153 WP_014391177.1 hypothetical protein -
QM029_RS04765 (QM029_04765) 970925..973111 - 2187 WP_014667973.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 969868..970029 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T282404 WP_014667974.1 NZ_CP125806:c968574-968290 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT282404 WP_014391174.1 NZ_CP125806:c968293-968000 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References