Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-YafN
Location 1521479..1522017 Replicon chromosome
Accession NZ_CP125805
Organism Mannheimia bovis strain 39324.S-11

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QMO40_RS07365 Protein ID WP_283385805.1
Coordinates 1521730..1522017 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID -
Locus tag QMO40_RS07360 Protein ID WP_283385804.1
Coordinates 1521479..1521733 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMO40_RS07340 (QMO40_07340) 1516603..1518066 + 1464 WP_283385800.1 IMP dehydrogenase -
QMO40_RS07345 (QMO40_07345) 1518150..1518809 + 660 WP_283385801.1 HAD family phosphatase -
QMO40_RS07350 (QMO40_07350) 1518841..1519776 + 936 WP_283385802.1 DUF2806 domain-containing protein -
QMO40_RS07355 (QMO40_07355) 1519787..1521358 + 1572 WP_283385803.1 glutamine-hydrolyzing GMP synthase -
QMO40_RS07360 (QMO40_07360) 1521479..1521733 + 255 WP_283385804.1 plasmid stabilization protein Antitoxin
QMO40_RS07365 (QMO40_07365) 1521730..1522017 + 288 WP_283385805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMO40_RS07370 (QMO40_07370) 1522054..1522287 - 234 WP_283385806.1 helix-turn-helix transcriptional regulator -
QMO40_RS07375 (QMO40_07375) 1522398..1522919 + 522 WP_283385807.1 hypothetical protein -
QMO40_RS07380 (QMO40_07380) 1522985..1524349 - 1365 WP_283385808.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
QMO40_RS07385 (QMO40_07385) 1524627..1525715 + 1089 WP_283385809.1 ionic transporter y4hA -
QMO40_RS07390 (QMO40_07390) 1525829..1526455 + 627 WP_025236107.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.35 Da        Isoelectric Point: 10.6648

>T282402 WP_283385805.1 NZ_CP125805:1521730-1522017 [Mannheimia bovis]
MKYTIEFIKSSEKEFRKLDLALRKQFVEKLKERAENPRVESAKLRGMKDCYKIKLRNSGYRLVYQVIDDRVVVKVIAVGK
RERNDVYQKASMRLS

Download         Length: 288 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9498.92 Da        Isoelectric Point: 4.0329

>AT282402 WP_283385804.1 NZ_CP125805:1521479-1521733 [Mannheimia bovis]
MPNIILTNTVASITELKTNPMATMRAAAGEPIAILNRNEPAFYCVPPHIYEYLMELADDAELAKIVEERQFEESYEIELA
DLLK

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References