Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 711977..712608 Replicon chromosome
Accession NZ_CP125805
Organism Mannheimia bovis strain 39324.S-11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMO40_RS03600 Protein ID WP_283386768.1
Coordinates 712210..712608 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W0QAN9
Locus tag QMO40_RS03595 Protein ID WP_025236825.1
Coordinates 711977..712210 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMO40_RS03565 (QMO40_03565) 707091..707408 - 318 WP_025236829.1 hypothetical protein -
QMO40_RS03570 (QMO40_03570) 707405..708613 - 1209 WP_283386765.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
QMO40_RS03575 (QMO40_03575) 708771..709469 + 699 WP_283386766.1 DNA repair protein RadC -
QMO40_RS03580 (QMO40_03580) 709731..709967 + 237 WP_006251446.1 50S ribosomal protein L28 -
QMO40_RS03585 (QMO40_03585) 709979..710149 + 171 WP_005613503.1 50S ribosomal protein L33 -
QMO40_RS03590 (QMO40_03590) 710460..711824 + 1365 WP_283386767.1 diaminobutyrate--2-oxoglutarate transaminase -
QMO40_RS03595 (QMO40_03595) 711977..712210 + 234 WP_025236825.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QMO40_RS03600 (QMO40_03600) 712210..712608 + 399 WP_283386768.1 tRNA(fMet)-specific endonuclease VapC Toxin
QMO40_RS03605 (QMO40_03605) 712628..714163 + 1536 WP_283386769.1 L-2,4-diaminobutyrate decarboxylase -
QMO40_RS03610 (QMO40_03610) 714252..714824 - 573 WP_283386770.1 NAD(P)H-dependent oxidoreductase -
QMO40_RS03615 (QMO40_03615) 714998..715531 + 534 WP_283387070.1 ferredoxin-type protein NapF -
QMO40_RS03620 (QMO40_03620) 715528..715794 + 267 WP_025236820.1 chaperone NapD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15102.52 Da        Isoelectric Point: 8.8588

>T282401 WP_283386768.1 NZ_CP125805:712210-712608 [Mannheimia bovis]
MLKYMLDTNIVIYIIKRRPIEVLHRFNQNAGRMCVSSITAAELYYGAEKSEFPTRNLAIIEDFLSRLTILDYQLKSAAHF
GNIKANLAKQGKLIGENDIHIAAHARSEGLIVVTNNLKEFERVEGLRLENWI

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8923.06 Da        Isoelectric Point: 4.4013

>AT282401 WP_025236825.1 NZ_CP125805:711977-712210 [Mannheimia bovis]
MIEASIFMTNRSQAVRLPAEVRFESDVKKIAVRVVGNERILSPINQSWDSFFLSNNTVSDDFMAEREITLQPEREDF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W0QAN9

References