282400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 312517..313157 Replicon chromosome
Accession NZ_CP125805
Organism Mannheimia bovis strain 39324.S-11

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag QMO40_RS01510 Protein ID WP_283386521.1
Coordinates 312517..312921 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag QMO40_RS01515 Protein ID WP_283386522.1
Coordinates 312918..313157 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMO40_RS01495 (QMO40_01495) 311108..311410 - 303 WP_283386519.1 hypothetical protein -
QMO40_RS01500 (QMO40_01500) 311422..311862 - 441 WP_283386520.1 hypothetical protein -
QMO40_RS01505 (QMO40_01505) 312077..312337 + 261 WP_176807923.1 helix-turn-helix transcriptional regulator -
QMO40_RS01510 (QMO40_01510) 312517..312921 - 405 WP_283386521.1 type II toxin-antitoxin system VapC family toxin Toxin
QMO40_RS01515 (QMO40_01515) 312918..313157 - 240 WP_283386522.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QMO40_RS01520 (QMO40_01520) 313412..313777 - 366 WP_005621166.1 50S ribosomal protein L7/L12 -
QMO40_RS01525 (QMO40_01525) 313833..314324 - 492 WP_025235143.1 50S ribosomal protein L10 -
QMO40_RS01530 (QMO40_01530) 314611..315300 - 690 WP_025235142.1 50S ribosomal protein L1 -
QMO40_RS01535 (QMO40_01535) 315305..315733 - 429 WP_025235141.1 50S ribosomal protein L11 -
QMO40_RS01540 (QMO40_01540) 316148..316711 - 564 WP_025235140.1 transcription termination/antitermination protein NusG -
QMO40_RS01545 (QMO40_01545) 316713..317126 - 414 WP_025235139.1 preprotein translocase subunit SecE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-125)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15207.80 Da        Isoelectric Point: 7.6274

>T282400 WP_283386521.1 NZ_CP125805:c312921-312517 [Mannheimia bovis]
MIYMLDTNILIYLMKNRPLAVAERVAQLTPSDQLVMSFITYAELLKGANGSANPEKALANIEKLKQRISVVYPNEKICEF
YGVWANKLKLQGKPIGGNDLWIACYALACNAILVTHNVKEFERIEALNWQDWTC

Download         Length: 405 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9094.11 Da        Isoelectric Point: 3.9818

>AT282400 WP_283386522.1 NZ_CP125805:c313157-312918 [Mannheimia bovis]
MRTKVFQSGNSQAVRIPFDFRFDVDTVEILQGQNGDVILRPVKPQADMEFLALFSDFDDDFIQALEDRDTSPPQERDTL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References