Detailed information of TA system TA028240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 4757812..4758767
• Replicon: chromosome
• Accession: NC_018581
• Organism: Gordonia sp. KTR9

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: J9SGC5
• Locus tag: KTR9_RS21980
• Protein ID: WP_014928188.1
• Coordinates: 4757812..4758387 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: J9SA71
• Locus tag: KTR9_RS21985
• Protein ID: WP_014928189.1
• Coordinates: 4758384..4758767 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR9_RS21955	4754057..4755064	+	1008	WP_014928184.1	LacI family transcriptional regulator	-
KTR9_RS21960	4755082..4755396	-	315	WP_014928185.1	DUF2470 domain-containing protein	-
KTR9_RS21965	4755389..4756120	-	732	WP_014928186.1	tyrosine-protein phosphatase	-
KTR9_RS21970	4756213..4756845	+	633	WP_010842697.1	flavin reductase family protein	-
KTR9_RS21975	4756868..4757815	-	948	WP_014928187.1	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	-
KTR9_RS21980	4757812..4758387	-	576	WP_014928188.1	zeta toxin family protein	Toxin
KTR9_RS21985	4758384..4758767	-	384	WP_014928189.1	hypothetical protein	Antitoxin
KTR9_RS21990	4758891..4759439	-	549	WP_014928190.1	peptide-methionine (S)-S-oxide reductase MsrA	-
KTR9_RS21995	4759436..4759930	-	495	WP_044508193.1	peptide-methionine (R)-S-oxide reductase MsrB	-
KTR9_RS22000	4760072..4760563	+	492	WP_010842691.1	SRPBCC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (2-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-70)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21271.39 Da
• Isoelectric Point: 8.9413

>T28240 WP_014928188.1 NC_018581:c4758387-4757812 [Gordonia sp. KTR9]
VTPRLDLVVGCDGAGKSTLVEHHLQPLLHTPFVNADLIARQKWPDAAEAHSYDAARLAAATRDKLIGTGASFIAETVFSH
PSKLELIERAHAAGYRVVLHVVMIPEDLAVHRVRLRVDSGGHAVPEVKIRERFRRLWPLVRTAILRSEQATVYANERPTT
RIVARYVDGMVAGMPDWPDWTPDAPTRSEPR

Nucleotide

• Length: 576 bp

>T28240 NC_018581:c4758387-4757812 [Gordonia sp. KTR9]
GTGACACCGCGGCTCGACCTGGTCGTCGGGTGTGATGGCGCGGGGAAGTCGACGCTGGTCGAGCATCATCTGCAGCCCTT
GCTGCACACGCCCTTCGTGAACGCCGACCTGATCGCCCGGCAGAAGTGGCCCGACGCCGCGGAAGCGCATTCCTACGACG
CCGCCCGACTGGCGGCGGCCACCCGCGACAAACTGATCGGGACAGGCGCCTCGTTCATCGCCGAGACGGTCTTTTCGCAT
CCATCCAAACTGGAACTCATCGAACGTGCGCACGCCGCCGGCTACCGAGTGGTGCTCCACGTCGTGATGATCCCCGAGGA
TCTCGCGGTCCATCGCGTCCGGTTGCGCGTCGACAGCGGTGGGCACGCGGTCCCGGAGGTCAAGATCCGCGAGCGGTTCC
GGCGCCTGTGGCCGCTCGTCCGCACGGCCATCCTCCGTAGCGAGCAGGCAACCGTGTACGCCAACGAGCGACCGACCACG
CGCATCGTCGCGCGGTACGTCGACGGTATGGTCGCGGGCATGCCCGACTGGCCGGACTGGACGCCGGATGCGCCGACGCG
TTCGGAGCCACGATGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 13803.24 Da
• Isoelectric Point: 5.6423

>AT28240 WP_014928189.1 NC_018581:c4758767-4758384 [Gordonia sp. KTR9]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRRRVEAALAGDLPGEVLTAEEAVVYDAEI
DAHLEARLATDDHVVRRASDGFSSVVVDDDGRLVEHRPDGTTVILGR

Nucleotide

• Length: 384 bp

>AT28240 NC_018581:c4758767-4758384 [Gordonia sp. KTR9]
ATGAGCACGGGTACGGACAAGGTGACCCGGCTGTCTGCCGCATTGGTGACCGATGCCGCCCGGGAGGGCGCGCGCGAGCA
GCGGTCAGCGCGGCAGCAACTCGAACACTGGGCCCGTCTCGGCCGCAGCGTCTCGCAGCGCACCACCGCGTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCGGGCGACTTGCCGGGAGAGGTGTTGACCGCCGAGGAAGCCGTCGTCTACGACGCCGAGATC
GACGCGCACCTCGAAGCGCGACTCGCCACCGACGACCACGTGGTTCGTCGTGCATCGGACGGGTTCTCCTCGGTCGTCGT
CGATGACGACGGACGGCTAGTCGAACACCGTCCCGACGGGACGACGGTCATCCTCGGCCGGTGA

Structures

Toxin

• AlphaFold DB: J9SGC5

Antitoxin

• AlphaFold DB: J9SA71