282399

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-YefM
Location 260095..260783 Replicon chromosome
Accession NZ_CP125805
Organism Mannheimia bovis strain 39324.S-11

Toxin (Protein)


Gene name vapC Uniprot ID W0Q2A7
Locus tag QMO40_RS01245 Protein ID WP_025235180.1
Coordinates 260095..260517 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMO40_RS01250 Protein ID WP_283386486.1
Coordinates 260517..260783 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMO40_RS01225 (QMO40_01225) 256138..257199 + 1062 WP_283386482.1 NADH:flavin oxidoreductase/NADH oxidase -
QMO40_RS01230 (QMO40_01230) 257224..257883 + 660 WP_283386483.1 NAD(P)H-dependent oxidoreductase -
QMO40_RS01235 (QMO40_01235) 258017..259075 + 1059 WP_283386484.1 NAD(P)-dependent alcohol dehydrogenase -
QMO40_RS01240 (QMO40_01240) 259205..260095 - 891 WP_283386485.1 LysR family transcriptional regulator -
QMO40_RS01245 (QMO40_01245) 260095..260517 - 423 WP_025235180.1 type II toxin-antitoxin system VapC family toxin Toxin
QMO40_RS01250 (QMO40_01250) 260517..260783 - 267 WP_283386486.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QMO40_RS01255 (QMO40_01255) 261015..261863 + 849 WP_283386487.1 MBL fold metallo-hydrolase -
QMO40_RS01260 (QMO40_01260) 261911..262570 + 660 WP_283386488.1 NAD(P)H-binding protein -
QMO40_RS01265 (QMO40_01265) 262611..263756 - 1146 WP_283386489.1 FMN-dependent L-lactate dehydrogenase LldD -
QMO40_RS01270 (QMO40_01270) 264365..265009 + 645 WP_283386490.1 RNA pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-64)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15907.45 Da        Isoelectric Point: 7.5204

>T282399 WP_025235180.1 NZ_CP125805:c260517-260095 [Mannheimia bovis]
MFLLDTNVVSELRKVKKGMANPNVVAWLAKQNPNDFYINSIVLMELERGVLAMERKDPTQGVHLRHWQNLFLNQILHKPI
LPIDETTAQICAKLHIPDHAPENDAWIAASAIQHHLILVTRNTADFAKTGAKLFNPFEPQ

Download         Length: 423 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.36 Da        Isoelectric Point: 5.6907

>AT282399 WP_283386486.1 NZ_CP125805:c260783-260517 [Mannheimia bovis]
MSVMTCREFNQKTSLAQKYAETAPVIITHRGKPTFVLLKYEDYQPQKNARSALDALLDLDHSPDVADIELELKPRSRAQR
PPVDFGDE

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0Q2A7

Antitoxin

Source ID Structure

References