282395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3592766..3593445 Replicon chromosome
Accession NZ_CP125781
Organism Trabulsiella odontotermitis strain TBY01

Toxin (Protein)


Gene name ykfI Uniprot ID S1FHS4
Locus tag QMG90_RS17035 Protein ID WP_000854680.1
Coordinates 3593104..3593445 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A5C1BXL1
Locus tag QMG90_RS17030 Protein ID WP_023336793.1
Coordinates 3592766..3593083 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG90_RS16985 (QMG90_16985) 3588203..3589024 + 822 WP_000197389.1 DUF932 domain-containing protein -
QMG90_RS16990 (QMG90_16990) 3589241..3589942 + 702 WP_006812588.1 WYL domain-containing protein -
QMG90_RS16995 (QMG90_16995) 3589983..3590219 + 237 WP_001144031.1 protein YpjK -
QMG90_RS17000 (QMG90_17000) 3590219..3590662 + 444 WP_000824223.1 lipoprotein YafY -
QMG90_RS17005 (QMG90_17005) 3590686..3591153 + 468 WP_001581459.1 protein YkfB -
QMG90_RS17010 (QMG90_17010) 3591230..3591469 + 240 WP_000194654.1 DUF905 family protein -
QMG90_RS17015 (QMG90_17015) 3591567..3592025 + 459 WP_000211838.1 antirestriction protein -
QMG90_RS17020 (QMG90_17020) 3592041..3592517 + 477 WP_023336794.1 RadC family protein -
QMG90_RS17025 (QMG90_17025) 3592526..3592747 + 222 WP_000691994.1 DUF987 domain-containing protein -
QMG90_RS17030 (QMG90_17030) 3592766..3593083 + 318 WP_023336793.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
QMG90_RS17035 (QMG90_17035) 3593104..3593445 + 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI Toxin
QMG90_RS17045 (QMG90_17045) 3594014..3595267 - 1254 WP_283280800.1 glutamate-5-semialdehyde dehydrogenase -
QMG90_RS17050 (QMG90_17050) 3595278..3596381 - 1104 WP_283280802.1 glutamate 5-kinase -
QMG90_RS17055 (QMG90_17055) 3596682..3597779 + 1098 WP_283280804.1 porin -
QMG90_RS17060 (QMG90_17060) 3597834..3598235 - 402 WP_283280805.1 sigma factor-binding protein Crl -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12892.95 Da        Isoelectric Point: 9.6543

>T282395 WP_000854680.1 NZ_CP125781:3593104-3593445 [Trabulsiella odontotermitis]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12016.63 Da        Isoelectric Point: 7.0270

>AT282395 WP_023336793.1 NZ_CP125781:3592766-3593083 [Trabulsiella odontotermitis]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHS4

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BXL1

References