Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3457488..3458109 Replicon chromosome
Accession NZ_CP125781
Organism Trabulsiella odontotermitis strain TBY01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QMG90_RS16380 Protein ID WP_283280708.1
Coordinates 3457903..3458109 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QMG90_RS16375 Protein ID WP_283280707.1
Coordinates 3457488..3457901 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG90_RS16355 (QMG90_16355) 3453422..3453880 - 459 WP_283280702.1 Lrp/AsnC family transcriptional regulator -
QMG90_RS16360 (QMG90_16360) 3454048..3454866 - 819 WP_283280703.1 HMP-PP phosphatase -
QMG90_RS16365 (QMG90_16365) 3454992..3456707 + 1716 WP_283280704.1 SgrR family transcriptional regulator -
QMG90_RS16370 (QMG90_16370) 3456760..3457455 + 696 WP_283280706.1 7-cyano-7-deazaguanine synthase QueC -
QMG90_RS16375 (QMG90_16375) 3457488..3457901 - 414 WP_283280707.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QMG90_RS16380 (QMG90_16380) 3457903..3458109 - 207 WP_283280708.1 type II toxin-antitoxin system HicA family toxin Toxin
QMG90_RS16385 (QMG90_16385) 3458161..3458559 - 399 WP_283280709.1 YbgC/FadM family acyl-CoA thioesterase -
QMG90_RS16390 (QMG90_16390) 3458667..3459038 - 372 WP_283280710.1 helix-hairpin-helix domain-containing protein -
QMG90_RS16395 (QMG90_16395) 3459187..3461061 - 1875 WP_283280711.1 peptidylprolyl isomerase -
QMG90_RS16400 (QMG90_16400) 3461263..3461535 - 273 WP_007373541.1 nucleoid-associated protein HU-beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3449834..3466310 16476


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7695.07 Da        Isoelectric Point: 11.6157

>T282394 WP_283280708.1 NZ_CP125781:c3458109-3457903 [Trabulsiella odontotermitis]
MNSKALIAELIADGWILIRVTGSHHHFRHPIKRGLVTVPHPKKDLPVGTVKSIRRQAGYENPLALPWR

Download         Length: 207 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15063.27 Da        Isoelectric Point: 4.4926

>AT282394 WP_283280707.1 NZ_CP125781:c3457901-3457488 [Trabulsiella odontotermitis]
MYYPIVVESGDEKHAWGVIVPDLPGCFSAGDTLDEAIVNAREAITAHIELLVEMGEDIPLISTVNDLVAQPQYQGMTWAL
VDIDVSRLLGGSEKINVTLPKSLIDRIDRCVARHPEFKSRSGFLAQAALERITKPFS

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References