282384

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3083222..3084138 Replicon chromosome
Accession NZ_CP125762
Organism Bacillus subtilis strain KRS015

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag QLQ05_RS16545 Protein ID WP_003244695.1
Coordinates 3083222..3083968 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag QLQ05_RS16550 Protein ID WP_003232646.1
Coordinates 3083968..3084138 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ05_RS16520 (3078303) 3078303..3078449 - 147 WP_003244977.1 hypothetical protein -
QLQ05_RS16525 (3078550) 3078550..3079500 - 951 WP_003245086.1 ring-cleaving dioxygenase -
QLQ05_RS16530 (3079889) 3079889..3081205 + 1317 WP_003244819.1 serine/threonine exchanger -
QLQ05_RS16535 (3081481) 3081481..3082098 + 618 WP_003218470.1 DUF47 domain-containing protein -
QLQ05_RS16540 (3082111) 3082111..3083112 + 1002 WP_003232642.1 inorganic phosphate transporter -
QLQ05_RS16545 (3083222) 3083222..3083968 + 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QLQ05_RS16550 (3083968) 3083968..3084138 + 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
QLQ05_RS16555 (3084224) 3084224..3084361 + 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QLQ05_RS16560 (3084398) 3084398..3085291 - 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
QLQ05_RS16565 (3085304) 3085304..3085567 - 264 WP_003232653.1 phage holin -
QLQ05_RS16570 (3085580) 3085580..3085849 - 270 WP_003232655.1 hemolysin XhlA family protein -
QLQ05_RS16575 (3085902) 3085902..3086741 - 840 WP_003245597.1 phage-like element PBSX protein XepA -
QLQ05_RS16580 (3086785) 3086785..3086949 - 165 WP_003232658.1 XkdX family protein -
QLQ05_RS16585 (3086946) 3086946..3087275 - 330 WP_003232660.1 XkdW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T282384 WP_003244695.1 NZ_CP125762:3083222-3083968 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT282384 WP_003232646.1 NZ_CP125762:3083968-3084138 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References