28236

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 578498..579035 Replicon chromosome
Accession NC_018529
Organism Burkholderia pseudomallei BPC006

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag BPC006_RS20330 Protein ID WP_004549731.1
Coordinates 578498..578767 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag BPC006_RS20335 Protein ID WP_004525420.1
Coordinates 578751..579035 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPC006_RS39090 574242..575282 - 1041 WP_197970191.1 ImmA/IrrE family metallo-endopeptidase -
BPC006_RS20295 575498..575782 - 285 WP_009961460.1 type II toxin-antitoxin system HigB family toxin -
BPC006_RS39910 576686..576928 - 243 WP_009961458.1 hypothetical protein -
BPC006_RS39915 576976..577134 - 159 WP_004549802.1 hypothetical protein -
BPC006_RS20305 577131..577373 - 243 WP_004545584.1 hypothetical protein -
BPC006_RS20315 577511..577642 - 132 WP_009923452.1 bacteriophage protein Gp48 -
BPC006_RS20320 577652..577927 - 276 WP_025988352.1 hypothetical protein -
BPC006_RS20330 578498..578767 + 270 WP_004549731.1 BrnT family toxin Toxin
BPC006_RS20335 578751..579035 + 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
BPC006_RS20345 579682..580065 + 384 Protein_506 DDE-type integrase/transposase/recombinase -
BPC006_RS35185 580028..580456 + 429 Protein_507 IS110 family transposase -
BPC006_RS20350 580683..580799 - 117 Protein_508 IS3 family transposase -
BPC006_RS20355 581046..582506 + 1461 WP_011326543.1 metallophosphoesterase -
BPC006_RS20360 582665..583927 + 1263 WP_004537187.1 c-type cytochrome -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 515454..582506 67052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T28236 WP_004549731.1 NC_018529:578498-578767 [Burkholderia pseudomallei BPC006]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T28236 NC_018529:578498-578767 [Burkholderia pseudomallei BPC006]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT28236 WP_004525420.1 NC_018529:578751-579035 [Burkholderia pseudomallei BPC006]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT28236 NC_018529:578751-579035 [Burkholderia pseudomallei BPC006]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References