Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4725116..4725632 Replicon chromosome
Accession NZ_CP125734
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag QMW18_RS22865 Protein ID WP_004894697.1
Coordinates 4725116..4725400 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QMW18_RS22870 Protein ID WP_002886901.1
Coordinates 4725390..4725632 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS22840 (QMW18_22840) 4720511..4720774 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
QMW18_RS22845 (QMW18_22845) 4720904..4721077 + 174 WP_002886906.1 hypothetical protein -
QMW18_RS22850 (QMW18_22850) 4721080..4721823 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
QMW18_RS22855 (QMW18_22855) 4722181..4724319 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
QMW18_RS22860 (QMW18_22860) 4724648..4725112 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QMW18_RS22865 (QMW18_22865) 4725116..4725400 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMW18_RS22870 (QMW18_22870) 4725390..4725632 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QMW18_RS22875 (QMW18_22875) 4725710..4727620 - 1911 WP_023325426.1 PRD domain-containing protein -
QMW18_RS22880 (QMW18_22880) 4727643..4728797 - 1155 WP_004178372.1 lactonase family protein -
QMW18_RS22885 (QMW18_22885) 4728864..4729604 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T282330 WP_004894697.1 NZ_CP125734:c4725400-4725116 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT282330 WP_002886901.1 NZ_CP125734:c4725632-4725390 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References