Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4655246..4655926 Replicon chromosome
Accession NZ_CP125734
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag QMW18_RS22550 Protein ID WP_040148945.1
Coordinates 4655246..4655566 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QMW18_RS22555 Protein ID WP_040148961.1
Coordinates 4655603..4655926 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS22520 (QMW18_22520) 4651061..4652188 + 1128 WP_023325431.1 PAAR domain-containing protein -
QMW18_RS22525 (QMW18_22525) 4652208..4652441 + 234 WP_014908049.1 hypothetical protein -
QMW18_RS22530 (QMW18_22530) 4652587..4652721 + 135 Protein_4417 transposase -
QMW18_RS22535 (QMW18_22535) 4652734..4652844 - 111 Protein_4418 DUF4102 domain-containing protein -
QMW18_RS22540 (QMW18_22540) 4653219..4654226 - 1008 WP_040148942.1 restriction endonuclease -
QMW18_RS22545 (QMW18_22545) 4654303..4655133 - 831 WP_040148943.1 DUF4942 domain-containing protein -
QMW18_RS22550 (QMW18_22550) 4655246..4655566 - 321 WP_040148945.1 TA system toxin CbtA family protein Toxin
QMW18_RS22555 (QMW18_22555) 4655603..4655926 - 324 WP_040148961.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMW18_RS22560 (QMW18_22560) 4655939..4656409 - 471 Protein_4423 DNA repair protein RadC -
QMW18_RS22565 (QMW18_22565) 4656480..4657301 - 822 WP_040148947.1 DUF932 domain-containing protein -
QMW18_RS22570 (QMW18_22570) 4657400..4657612 - 213 WP_040148948.1 hypothetical protein -
QMW18_RS22575 (QMW18_22575) 4657686..4658042 - 357 WP_223366209.1 hypothetical protein -
QMW18_RS22580 (QMW18_22580) 4658115..4658579 - 465 WP_040148963.1 hypothetical protein -
QMW18_RS22585 (QMW18_22585) 4659451..4660905 + 1455 WP_072042785.1 YfjI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4646934..4673087 26153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-105)

Antitoxin

Antitoxin CbeA

(8-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12089.67 Da        Isoelectric Point: 6.6413

>T282329 WP_040148945.1 NZ_CP125734:c4655566-4655246 [Klebsiella pneumoniae]
MHISTVPAKESVSSRLSPVQVWQQLLTYLLNHHYGLTLNDTPFHNDTAIQEHIEAGIALADAVNFLVERYELVRTDRKGF
TWQDQTPFLTTTDILRARRATGIINT

Download         Length: 321 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11951.67 Da        Isoelectric Point: 7.1306

>AT282329 WP_040148961.1 NZ_CP125734:c4655926-4655603 [Klebsiella pneumoniae]
MPFTLPNEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGEITPKQLQKLAQTFPLFISQLEAMLRSGELNSQQQHQVT
IQLASLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References