Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4618963..4619773 Replicon chromosome
Accession NZ_CP125734
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QMW18_RS22375 Protein ID WP_004178461.1
Coordinates 4618963..4619496 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QMW18_RS22380 Protein ID WP_002887278.1
Coordinates 4619507..4619773 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS22370 (QMW18_22370) 4617794..4618915 + 1122 WP_002887282.1 cupin domain-containing protein -
QMW18_RS22375 (QMW18_22375) 4618963..4619496 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QMW18_RS22380 (QMW18_22380) 4619507..4619773 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QMW18_RS22385 (QMW18_22385) 4619876..4621309 - 1434 WP_004894565.1 Cu(+)/Ag(+) sensor histidine kinase -
QMW18_RS22390 (QMW18_22390) 4621299..4621982 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QMW18_RS22395 (QMW18_22395) 4622154..4623539 + 1386 WP_032439492.1 efflux transporter outer membrane subunit -
QMW18_RS22400 (QMW18_22400) 4623557..4623901 + 345 WP_004894569.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T282328 WP_004178461.1 NZ_CP125734:c4619496-4618963 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT282328 WP_002887278.1 NZ_CP125734:c4619773-4619507 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References