Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2628608..2630196 Replicon chromosome
Accession NZ_CP125734
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag QMW18_RS12895 Protein ID WP_004892016.1
Coordinates 2628608..2629930 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QMW18_RS12900 Protein ID WP_004176198.1
Coordinates 2629930..2630196 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS12880 (QMW18_12880) 2623664..2626165 + 2502 WP_004892009.1 fimbria/pilus outer membrane usher protein -
QMW18_RS12885 (QMW18_12885) 2626153..2627157 + 1005 WP_004892012.1 fimbrial protein -
QMW18_RS12890 (QMW18_12890) 2627299..2628591 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QMW18_RS12895 (QMW18_12895) 2628608..2629930 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
QMW18_RS12900 (QMW18_12900) 2629930..2630196 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QMW18_RS12905 (QMW18_12905) 2630461..2630787 - 327 WP_004892019.1 hydroxyisourate hydrolase -
QMW18_RS12910 (QMW18_12910) 2630784..2631284 - 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QMW18_RS12915 (QMW18_12915) 2631262..2632641 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
QMW18_RS12920 (QMW18_12920) 2632987..2634141 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
QMW18_RS12925 (QMW18_12925) 2634122..2635045 - 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2426031..2665679 239648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T282324 WP_004892016.1 NZ_CP125734:c2629930-2628608 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT282324 WP_004176198.1 NZ_CP125734:c2630196-2629930 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References