Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 780977..781634 Replicon chromosome
Accession NZ_CP125734
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QMW18_RS03880 Protein ID WP_002916310.1
Coordinates 781224..781634 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QMW18_RS03875 Protein ID WP_002916312.1
Coordinates 780977..781243 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS03850 (QMW18_03850) 776133..777566 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QMW18_RS03855 (QMW18_03855) 777685..778413 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QMW18_RS03860 (QMW18_03860) 778463..778774 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QMW18_RS03865 (QMW18_03865) 778938..779597 + 660 WP_004889817.1 hemolysin III family protein -
QMW18_RS03870 (QMW18_03870) 779748..780731 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QMW18_RS03875 (QMW18_03875) 780977..781243 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QMW18_RS03880 (QMW18_03880) 781224..781634 + 411 WP_002916310.1 protein YgfX Toxin
QMW18_RS03885 (QMW18_03885) 781641..782162 - 522 WP_004144730.1 flavodoxin FldB -
QMW18_RS03890 (QMW18_03890) 782263..783159 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QMW18_RS03895 (QMW18_03895) 783182..783895 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QMW18_RS03900 (QMW18_03900) 783901..785634 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T282319 WP_002916310.1 NZ_CP125734:781224-781634 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT282319 WP_002916312.1 NZ_CP125734:780977-781243 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References