Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3520342..3520960 | Replicon | chromosome |
Accession | NZ_CP125731 | ||
Organism | Escherichia coli strain GYB01 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | QMW19_RS17090 | Protein ID | WP_001291435.1 |
Coordinates | 3520742..3520960 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | QMW19_RS17085 | Protein ID | WP_000344800.1 |
Coordinates | 3520342..3520716 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QMW19_RS17075 (3515431) | 3515431..3516624 | + | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
QMW19_RS17080 (3516647) | 3516647..3519796 | + | 3150 | WP_001132469.1 | efflux RND transporter permease AcrB | - |
QMW19_RS17085 (3520342) | 3520342..3520716 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
QMW19_RS17090 (3520742) | 3520742..3520960 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
QMW19_RS17095 (3521132) | 3521132..3521683 | + | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
QMW19_RS17100 (3521799) | 3521799..3522269 | + | 471 | WP_000136192.1 | YlaC family protein | - |
QMW19_RS17105 (3522433) | 3522433..3523983 | + | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
QMW19_RS17110 (3524025) | 3524025..3524378 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
QMW19_RS17120 (3524757) | 3524757..3525068 | + | 312 | WP_000409911.1 | MGMT family protein | - |
QMW19_RS17125 (3525099) | 3525099..3525671 | - | 573 | WP_000779831.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T282297 WP_001291435.1 NZ_CP125731:3520742-3520960 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT282297 WP_000344800.1 NZ_CP125731:3520342-3520716 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |