Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 542042..542618 Replicon chromosome
Accession NZ_CP125672
Organism Leptospira kirschneri strain 804Khv

Toxin (Protein)


Gene name chpK Uniprot ID A0A828YA21
Locus tag QMK36_RS02270 Protein ID WP_004755078.1
Coordinates 542277..542618 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID A0A828Y9A4
Locus tag QMK36_RS02265 Protein ID WP_004759478.1
Coordinates 542042..542290 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK36_RS02255 (QMK36_02255) 538521..539303 + 783 WP_004754327.1 ABC transporter ATP-binding protein -
QMK36_RS02260 (QMK36_02260) 539300..541837 + 2538 WP_004759514.1 FtsX-like permease family protein -
QMK36_RS02265 (QMK36_02265) 542042..542290 + 249 WP_004759478.1 hypothetical protein Antitoxin
QMK36_RS02270 (QMK36_02270) 542277..542618 + 342 WP_004755078.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QMK36_RS02275 (QMK36_02275) 542725..542874 + 150 WP_004759513.1 hypothetical protein -
QMK36_RS02280 (QMK36_02280) 543691..543978 - 288 WP_004754874.1 hypothetical protein -
QMK36_RS02285 (QMK36_02285) 544408..544956 - 549 WP_004754121.1 YqgE/AlgH family protein -
QMK36_RS02290 (QMK36_02290) 544980..545948 - 969 WP_004755369.1 Gfo/Idh/MocA family oxidoreductase -
QMK36_RS02295 (QMK36_02295) 546224..547342 - 1119 WP_004760477.1 molecular chaperone DnaJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12354.23 Da        Isoelectric Point: 5.1486

>T282275 WP_004755078.1 NZ_CP125672:542277-542618 [Leptospira kirschneri]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNISTVVSIAITSNLNLSEAPGNVLIGKKESSLSKDSVVNVSQIV
TLDKERFIERVGKLKSSKINEVEVGLKLVTGLD

Download         Length: 342 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9422.94 Da        Isoelectric Point: 10.4447

>AT282275 WP_004759478.1 NZ_CP125672:542042-542290 [Leptospira kirschneri]
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYNRKSKELKSNITDLSVELLRKSLKND
SW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828YA21

Antitoxin

Source ID Structure
AlphaFold DB A0A828Y9A4

References