Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1348050..1348966 Replicon chromosome
Accession NZ_CP125660
Organism Bacillus subtilis strain GUCC48

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag QLH41_RS07095 Protein ID WP_003244695.1
Coordinates 1348220..1348966 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag QLH41_RS07090 Protein ID WP_003232646.1
Coordinates 1348050..1348220 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLH41_RS07055 (1344913) 1344913..1345242 + 330 WP_003232660.1 XkdW family protein -
QLH41_RS07060 (1345239) 1345239..1345403 + 165 WP_003232658.1 XkdX family protein -
QLH41_RS07065 (1345447) 1345447..1346286 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
QLH41_RS07070 (1346339) 1346339..1346608 + 270 WP_003232655.1 hemolysin XhlA family protein -
QLH41_RS07075 (1346621) 1346621..1346884 + 264 WP_003232653.1 phage holin -
QLH41_RS07080 (1346897) 1346897..1347790 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
QLH41_RS07085 (1347827) 1347827..1347964 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QLH41_RS07090 (1348050) 1348050..1348220 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
QLH41_RS07095 (1348220) 1348220..1348966 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QLH41_RS07100 (1349076) 1349076..1350077 - 1002 WP_003232642.1 inorganic phosphate transporter -
QLH41_RS07105 (1350090) 1350090..1350707 - 618 WP_003218470.1 DUF47 domain-containing protein -
QLH41_RS07110 (1350983) 1350983..1352299 - 1317 WP_003244819.1 serine/threonine exchanger -
QLH41_RS07115 (1352688) 1352688..1353638 + 951 WP_003245086.1 ring-cleaving dioxygenase -
QLH41_RS07120 (1353739) 1353739..1353885 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T282250 WP_003244695.1 NZ_CP125660:c1348966-1348220 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT282250 WP_003232646.1 NZ_CP125660:c1348220-1348050 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References