Detailed information of TA system TA282248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1113350..1113843
• Replicon: chromosome
• Accession: NZ_CP125658
• Organism: Enterococcus sp. ZQ21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: QK255_RS05430
• Protein ID: WP_002292138.1
• Coordinates: 1113577..1113843 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: QK255_RS05425
• Protein ID: WP_002292139.1
• Coordinates: 1113350..1113580 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QK255_RS05400 (QK255_05400)	1109160..1109828	+	669	WP_002342166.1	zeta toxin family protein	-
QK255_RS05405 (QK255_05405)	1109821..1109982	+	162	WP_002342167.1	hypothetical protein	-
QK255_RS05410 (QK255_05410)	1110192..1110623	+	432	WP_002342168.1	N-6 DNA methylase	-
QK255_RS05415 (QK255_05415)	1111098..1112057	+	960	WP_002362389.1	IS30-like element IS6770 family transposase	-
QK255_RS05420 (QK255_05420)	1112193..1112858	+	666	WP_002292140.1	hypothetical protein	-
QK255_RS05425 (QK255_05425)	1113350..1113580	+	231	WP_002292139.1	DUF6290 family protein	Antitoxin
QK255_RS05430 (QK255_05430)	1113577..1113843	+	267	WP_002292138.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QK255_RS05435 (QK255_05435)	1114095..1114322	+	228	WP_002313668.1	hypothetical protein	-
QK255_RS05440 (QK255_05440)	1114338..1115504	+	1167	WP_002292137.1	radical SAM family heme chaperone HemW	-
QK255_RS05445 (QK255_05445)	1115738..1116781	+	1044	WP_002292136.1	heat-inducible transcriptional repressor HrcA	-
QK255_RS05450 (QK255_05450)	1116875..1117438	+	564	WP_002292135.1	nucleotide exchange factor GrpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1111098..1112057	959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.21 Da
• Isoelectric Point: 10.3338

>T282248 WP_002292138.1 NZ_CP125658:1113577-1113843 [Enterococcus sp. ZQ21]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQIVVIAIQV
GHRKNVYD

Nucleotide

• Length: 267 bp

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8883.02 Da
• Isoelectric Point: 4.1943

>AT282248 WP_002292139.1 NZ_CP125658:1113350-1113580 [Enterococcus sp. ZQ21]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILREFGGLE

Nucleotide

• Length: 231 bp