Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 750042..750702 Replicon chromosome
Accession NC_018525
Organism Pectobacterium carotovorum subsp. carotovorum PCC21

Toxin (Protein)


Gene name cptA Uniprot ID A0A837DIN4
Locus tag PCC21_RS03360 Protein ID WP_039275532.1
Coordinates 750289..750702 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag PCC21_RS03355 Protein ID WP_005971623.1
Coordinates 750042..750308 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC21_RS03335 746005..747009 - 1005 WP_014914173.1 LacI family DNA-binding transcriptional regulator -
PCC21_RS03340 747064..747672 - 609 WP_014914174.1 HD domain-containing protein -
PCC21_RS03345 748103..748750 + 648 WP_010279833.1 hemolysin III family protein -
PCC21_RS03350 748805..749806 - 1002 WP_014914175.1 tRNA-modifying protein YgfZ -
PCC21_RS03355 750042..750308 + 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
PCC21_RS03360 750289..750702 + 414 WP_039275532.1 protein YgfX Toxin
PCC21_RS03365 750771..751706 + 936 WP_014914176.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
PCC21_RS03370 751772..752095 - 324 WP_014914177.1 hypothetical protein -
PCC21_RS03375 752124..752642 - 519 WP_014914178.1 flavodoxin FldB -
PCC21_RS03380 752985..753371 - 387 WP_014914179.1 hypothetical protein -
PCC21_RS03385 753576..754904 - 1329 WP_014914180.1 MHS family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16311.26 Da        Isoelectric Point: 10.7911

>T28224 WP_039275532.1 NC_018525:750289-750702 [Pectobacterium carotovorum subsp. carotovorum PCC21]
VAQWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Download         Length: 414 bp

>T28224 NC_018525:750289-750702 [Pectobacterium carotovorum subsp. carotovorum PCC21]
GTGGCCCAGTGGCGATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGTTATCATTGGTTGTGCATGGCCTATTAGTATT
GCTCATTCTGCTGGCACCCTGGCCGGACGGCTATGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAACGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGTTGCTGAAGAATGGCGTATTACTGTCATTGCAAGCGGTTAACGGTAAAGACAA
GCAGCAGCTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGCCACTTGCGTCAAATTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT28224 WP_005971623.1 NC_018525:750042-750308 [Pectobacterium carotovorum subsp. carotovorum PCC21]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT28224 NC_018525:750042-750308 [Pectobacterium carotovorum subsp. carotovorum PCC21]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACACTGATAAGCGCACGTTTGTACGCTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGGAGGACGGAGAGCTGAAACGCATGATTTCCCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837DIN4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References