Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3786186..3786853 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag O3Q54_RS17845 Protein ID WP_003417916.1
Coordinates 3786186..3786578 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag O3Q54_RS17850 Protein ID WP_003912214.1
Coordinates 3786578..3786853 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS17830 (O3Q54_17830) 3782206..3783361 - 1156 Protein_3522 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
O3Q54_RS17835 (O3Q54_17835) 3783391..3784380 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
O3Q54_RS17840 (O3Q54_17840) 3784380..3785432 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
O3Q54_RS17845 (O3Q54_17845) 3786186..3786578 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS17850 (O3Q54_17850) 3786578..3786853 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3Q54_RS17855 (O3Q54_17855) 3787035..3788406 + 1372 Protein_3527 ISNCY family transposase -
O3Q54_RS17860 (O3Q54_17860) 3788596..3790791 + 2196 WP_010886168.1 PE family protein -
O3Q54_RS17865 (O3Q54_17865) 3790862..3791734 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3787729..3788406 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T282220 WP_003417916.1 NZ_CP125620:c3786578-3786186 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT282220 WP_003912214.1 NZ_CP125620:c3786853-3786578 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References