Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3757716..3758245 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag O3Q54_RS17710 Protein ID WP_003417760.1
Coordinates 3757988..3758245 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag O3Q54_RS17705 Protein ID WP_003417757.1
Coordinates 3757716..3757991 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS17670 (O3Q54_17670) 3754289..3754978 - 690 WP_003917774.1 BBE domain-containing protein -
O3Q54_RS17675 (O3Q54_17675) 3755165..3755536 - 372 WP_003417739.1 FAD-binding protein -
O3Q54_RS17680 (O3Q54_17680) 3755434..3755652 - 219 WP_157132559.1 hypothetical protein -
O3Q54_RS17685 (O3Q54_17685) 3755679..3755939 - 261 WP_003417741.1 hypothetical protein -
O3Q54_RS17690 (O3Q54_17690) 3756054..3756443 + 390 WP_003417745.1 DUF732 domain-containing protein -
O3Q54_RS17695 (O3Q54_17695) 3756457..3756750 - 294 WP_003417749.1 DUF3017 domain-containing protein -
O3Q54_RS17700 (O3Q54_17700) 3756747..3757592 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
O3Q54_RS17705 (O3Q54_17705) 3757716..3757991 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
O3Q54_RS17710 (O3Q54_17710) 3757988..3758245 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
O3Q54_RS17715 (O3Q54_17715) 3758287..3759477 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
O3Q54_RS17720 (O3Q54_17720) 3759594..3759962 + 369 WP_003417765.1 FHA domain-containing protein -
O3Q54_RS17725 (O3Q54_17725) 3759959..3760510 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
O3Q54_RS17730 (O3Q54_17730) 3760517..3761098 - 582 WP_003417769.1 ATP/GTP-binding protein -
O3Q54_RS17735 (O3Q54_17735) 3761079..3761447 - 369 WP_003417772.1 DUF742 domain-containing protein -
O3Q54_RS17740 (O3Q54_17740) 3761425..3761817 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T282219 WP_003417760.1 NZ_CP125620:3757988-3758245 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT282219 WP_003417757.1 NZ_CP125620:3757716-3757991 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References