282218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3689190..3689864 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag O3Q54_RS17490 Protein ID WP_003417282.1
Coordinates 3689190..3689618 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag O3Q54_RS17495 Protein ID WP_003417286.1
Coordinates 3689622..3689864 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS17465 (O3Q54_17465) 3685012..3685413 - 402 WP_003417264.1 cytidine deaminase -
O3Q54_RS17470 (O3Q54_17470) 3685650..3685988 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
O3Q54_RS17475 (O3Q54_17475) 3685985..3686419 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
O3Q54_RS17480 (O3Q54_17480) 3686548..3688320 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
O3Q54_RS17485 (O3Q54_17485) 3688320..3689111 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
O3Q54_RS17490 (O3Q54_17490) 3689190..3689618 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS17495 (O3Q54_17495) 3689622..3689864 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
O3Q54_RS17500 (O3Q54_17500) 3689986..3690600 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
O3Q54_RS17505 (O3Q54_17505) 3690597..3691262 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
O3Q54_RS17510 (O3Q54_17510) 3691263..3691796 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
O3Q54_RS17515 (O3Q54_17515) 3691793..3692167 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
O3Q54_RS17525 (O3Q54_17525) 3693622..3694758 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T282218 WP_003417282.1 NZ_CP125620:c3689618-3689190 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT282218 WP_003417286.1 NZ_CP125620:c3689864-3689622 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References