Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3166020..3166707 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag O3Q54_RS15115 Protein ID WP_003414624.1
Coordinates 3166264..3166707 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag O3Q54_RS15110 Protein ID WP_003414620.1
Coordinates 3166020..3166277 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS15090 (O3Q54_15090) 3161340..3162194 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
O3Q54_RS15095 (O3Q54_15095) 3162250..3163413 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
O3Q54_RS15100 (O3Q54_15100) 3163430..3164644 - 1215 WP_003899518.1 zinc metalloprotease Rip -
O3Q54_RS15105 (O3Q54_15105) 3164652..3165893 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
O3Q54_RS15110 (O3Q54_15110) 3166020..3166277 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
O3Q54_RS15115 (O3Q54_15115) 3166264..3166707 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS15120 (O3Q54_15120) 3166787..3167449 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
O3Q54_RS15125 (O3Q54_15125) 3167545..3167736 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
O3Q54_RS15130 (O3Q54_15130) 3168068..3169816 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
O3Q54_RS15135 (O3Q54_15135) 3169912..3170493 + 582 WP_003414644.1 fasciclin domain-containing protein -
O3Q54_RS15140 (O3Q54_15140) 3170593..3170859 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T282216 WP_003414624.1 NZ_CP125620:3166264-3166707 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT282216 WP_003414620.1 NZ_CP125620:3166020-3166277 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References