282212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3093762..3094332 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag O3Q54_RS14740 Protein ID WP_003414166.1
Coordinates 3093762..3094118 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag O3Q54_RS14745 Protein ID WP_003901465.1
Coordinates 3094102..3094332 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS14720 (O3Q54_14720) 3089214..3090902 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
O3Q54_RS14725 (O3Q54_14725) 3090906..3091232 - 327 WP_003414157.1 hypothetical protein -
O3Q54_RS14730 (O3Q54_14730) 3091405..3091992 + 588 WP_003914429.1 DUF3558 family protein -
O3Q54_RS14735 (O3Q54_14735) 3092011..3093660 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
O3Q54_RS14740 (O3Q54_14740) 3093762..3094118 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
O3Q54_RS14745 (O3Q54_14745) 3094102..3094332 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
O3Q54_RS14750 (O3Q54_14750) 3094375..3095418 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
O3Q54_RS14755 (O3Q54_14755) 3095417..3095884 + 468 WP_003414177.1 DUF1778 domain-containing protein -
O3Q54_RS14760 (O3Q54_14760) 3096060..3096314 - 255 WP_003917684.1 hypothetical protein -
O3Q54_RS14765 (O3Q54_14765) 3096462..3096866 + 405 WP_009938577.1 hypothetical protein -
O3Q54_RS14770 (O3Q54_14770) 3096863..3097054 + 192 WP_003414184.1 hypothetical protein -
O3Q54_RS14775 (O3Q54_14775) 3097271..3097531 + 261 Protein_2916 transposase -
O3Q54_RS14780 (O3Q54_14780) 3098641..3098898 + 258 WP_003899489.1 hypothetical protein -
O3Q54_RS14785 (O3Q54_14785) 3099003..3099314 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T282212 WP_003414166.1 NZ_CP125620:c3094118-3093762 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT282212 WP_003901465.1 NZ_CP125620:c3094332-3094102 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References