282208

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2914866..2915580 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag O3Q54_RS13690 Protein ID WP_003413460.1
Coordinates 2915140..2915580 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag O3Q54_RS13685 Protein ID WP_003413456.1
Coordinates 2914866..2915153 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS13650 (O3Q54_13650) 2910288..2910533 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
O3Q54_RS13655 (O3Q54_13655) 2910530..2910934 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
O3Q54_RS13660 (O3Q54_13660) 2911151..2911771 + 621 WP_003413441.1 DUF4178 domain-containing protein -
O3Q54_RS13665 (O3Q54_13665) 2911782..2912276 + 495 WP_003413444.1 DUF2617 family protein -
O3Q54_RS13670 (O3Q54_13670) 2912273..2912704 + 432 WP_003899390.1 DUF4247 domain-containing protein -
O3Q54_RS13675 (O3Q54_13675) 2912729..2913187 + 459 WP_003413451.1 DUF350 domain-containing protein -
O3Q54_RS13680 (O3Q54_13680) 2913184..2914755 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
O3Q54_RS13685 (O3Q54_13685) 2914866..2915153 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
O3Q54_RS13690 (O3Q54_13690) 2915140..2915580 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS13695 (O3Q54_13695) 2915601..2916356 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
O3Q54_RS13700 (O3Q54_13700) 2916489..2917085 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
O3Q54_RS13705 (O3Q54_13705) 2917093..2917938 - 846 WP_003413466.1 acyl-CoA thioesterase II -
O3Q54_RS13710 (O3Q54_13710) 2917967..2918866 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
O3Q54_RS13715 (O3Q54_13715) 2918994..2919668 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T282208 WP_003413460.1 NZ_CP125620:2915140-2915580 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT282208 WP_003413456.1 NZ_CP125620:2914866-2915153 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References