Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2792880..2793532 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag O3Q54_RS13125 Protein ID WP_003412752.1
Coordinates 2793107..2793532 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag O3Q54_RS13120 Protein ID WP_003412749.1
Coordinates 2792880..2793101 (+) Length 74 a.a.

Genomic Context

O3Q54_RS13110O3Q54_RS13115O3Q54_RS13120O3Q54_RS13125O3Q54_RS13105O3Q54_RS13130O3Q54_RS13135O3Q54_RS13140O3Q54_RS13145O3Q54_RS13150
Location: 2791462..2792085 (624 bp)
Type: Others
Protein ID: WP_003900858.1
Location: 2792075..2792827 (753 bp)
Type: Others
Protein ID: WP_003900859.1
Location: 2792880..2793101 (222 bp)
Type: Antitoxin
Protein ID: WP_003412749.1
Location: 2793107..2793532 (426 bp)
Type: Toxin
Protein ID: WP_003412752.1
Location: 2791120..2791326 (207 bp)
Type: Others
Protein ID: WP_003899347.1
Location: 2793555..2794736 (1182 bp)
Type: Others
Protein ID: WP_003899351.1
Location: 2794733..2795779 (1047 bp)
Type: Others
Protein ID: WP_003412757.1
Location: 2795790..2796893 (1104 bp)
Type: Others
Protein ID: WP_003412761.1
Location: 2797152..2797973 (822 bp)
Type: Others
Protein ID: WP_003412766.1
Location: 2797970..2798527 (558 bp)
Type: Others
Protein ID: WP_003412768.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Q54_RS13105 (O3Q54_13105)2791120..2791326-207WP_003899347.1hypothetical protein-
O3Q54_RS13110 (O3Q54_13110)2791462..2792085+624WP_003900858.1TIGR00725 family protein-
O3Q54_RS13115 (O3Q54_13115)2792075..2792827+753WP_003900859.1hypothetical protein-
O3Q54_RS13120 (O3Q54_13120)2792880..2793101+222WP_003412749.1antitoxinAntitoxin
O3Q54_RS13125 (O3Q54_13125)2793107..2793532+426WP_003412752.1type II toxin-antitoxin system VapC family toxinToxin
O3Q54_RS13130 (O3Q54_13130)2793555..2794736-1182WP_003899351.1dihydrolipoamide acetyltransferase family protein-
O3Q54_RS13135 (O3Q54_13135)2794733..2795779-1047WP_003412757.13-methyl-2-oxobutanoate dehydrogenase subunit beta-
O3Q54_RS13140 (O3Q54_13140)2795790..2796893-1104WP_003412761.1pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha-
O3Q54_RS13145 (O3Q54_13145)2797152..2797973-822WP_003412766.1citrate (pro-3S)-lyase subunit beta-
O3Q54_RS13150 (O3Q54_13150)2797970..2798527-558WP_003412768.1MaoC family dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T282203 WP_003412752.1 NZ_CP125620:2793107-2793532 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT282203 WP_003412749.1 NZ_CP125620:2792880-2793101 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TPX1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BW03

References