Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2386952..2387481 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag O3Q54_RS11195 Protein ID WP_003411124.1
Coordinates 2386952..2387269 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag O3Q54_RS11200 Protein ID WP_003411127.1
Coordinates 2387266..2387481 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS11165 (O3Q54_11165) 2382147..2383223 + 1077 WP_003411110.1 hypothetical protein -
O3Q54_RS11170 (O3Q54_11170) 2383220..2383501 + 282 WP_003411112.1 DUF5703 family protein -
O3Q54_RS11175 (O3Q54_11175) 2383537..2384610 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
O3Q54_RS11180 (O3Q54_11180) 2384615..2385145 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
O3Q54_RS11185 (O3Q54_11185) 2385193..2386539 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
O3Q54_RS11195 (O3Q54_11195) 2386952..2387269 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3Q54_RS11200 (O3Q54_11200) 2387266..2387481 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
O3Q54_RS11205 (O3Q54_11205) 2387736..2388794 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
O3Q54_RS11210 (O3Q54_11210) 2388924..2389280 - 357 WP_003411130.1 hypothetical protein -
O3Q54_RS11215 (O3Q54_11215) 2389375..2390157 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
O3Q54_RS11220 (O3Q54_11220) 2390425..2390715 - 291 WP_003900476.1 YggT family protein -
O3Q54_RS11225 (O3Q54_11225) 2390877..2391533 - 657 WP_003411133.1 cell division protein SepF -
O3Q54_RS11230 (O3Q54_11230) 2391599..2392375 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T282202 WP_003411124.1 NZ_CP125620:c2387269-2386952 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT282202 WP_003411127.1 NZ_CP125620:c2387481-2387266 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References